The relationship between gastrin cells and bombesin-like immunoreactive nerve fibres in the gastric antral mucosa of guinea-pig, rat, dog and man

A. S. Miller, J. B. Furness, M. Costa

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    The relationship between bombesin-like immunoreactive (bombesin-LI) nerve fibres and gastrin-LI G-cells was examined in gastric antral mucosa from guineapig, rat, dog and man using a double-labelling fluorescence immunohistochemical technique. The greatest density of bombesin-LI nerve fibres was found within the basal mucosa in all species and the density of innervation decreased towards the luminal surface. Most G-cells were in a band occupying approximately the middle third of the mucosa. The proportion of G-cells found within a distance of 2 μm from bombesin-LI nerve fibres was low in all species (6% in the guinea-pig, 22% in the rat, 14% in the dog, and 9% in the human). It is proposed that the neuropeptide released from bombesin-LI antral mucosal nerve fibres traverses distances of greater than several μm to reach the target G-cells. This may be achieved by passage through the mucosal microcirculation.

    Original languageEnglish
    Pages (from-to)171-178
    Number of pages8
    JournalCell and Tissue Research
    Volume257
    DOIs
    Publication statusPublished - Jul 1989

    Keywords

    • Autonomic innervation
    • Bombesin
    • Dog
    • Gastrin
    • Gastrin-releasing peptide
    • Guinea pig
    • Immunohistochemistry
    • Man
    • Rat
    • Stomach

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