The RNA interactome in the Hallmarks of Cancer

Marta M. Gabryelska, Simon J. Conn

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)
44 Downloads (Pure)

Abstract

Ribonucleic acid (RNA) molecules are indispensable for cellular homeostasis in healthy and malignant cells. However, the functions of RNA extend well beyond that of a protein-coding template. Rather, both coding and non-coding RNA molecules function through critical interactions with a plethora of cellular molecules, including other RNAs, DNA, and proteins. Deconvoluting this RNA interactome, including the interacting partners, the nature of the interaction, and dynamic changes of these interactions in malignancies has yielded fundamental advances in knowledge and are emerging as a novel therapeutic strategy in cancer. Here, we present an RNA-centric review of recent advances in the field of RNA–RNA, RNA–protein, and RNA–DNA interactomic network analysis and their impact across the Hallmarks of Cancer. 

This article is categorized under: 

RNA in Disease and Development > RNA in Disease
RNA Interactions with Proteins and Other Molecules > RNA–Protein Complexes.

Original languageEnglish
Article numbere1786
Number of pages27
JournalWiley Interdisciplinary Reviews: RNA
Volume14
Issue number5
Early online date12 Apr 2023
DOIs
Publication statusPublished - Sept 2023

Keywords

  • Hallmarks of Cancer
  • molecular biology
  • RNA interactomics
  • RNA–protein
  • RNA–RNA

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