The role of microRNAs in bovine infection and immunity

Nathan Lawless, Peter Vegh, Cliona O'Farrelly, David Lynn

    Research output: Contribution to journalArticle

    31 Citations (Scopus)

    Abstract

    MicroRNAs (miRNAs) are a class of small, non-coding RNAs that are recognized as critical regulators of immune gene expression during infection. Many immunologically significant human miRNAs have been found to be conserved in agriculturally important species, including cattle. Discovering how bovine miRNAs mediate the immune defense during infection is critical to understanding the etiology of the most prevalent bovine diseases. Here, we review current knowledge of miRNAs in the bovine genome, and discuss the advances in understanding of miRNAs as regulators of immune cell function, and bovine immune response activation, regulation, and resolution. Finally, we consider the future perspectives on miRNAs in bovine viral disease, their role as potential biomarkers and in therapy.

    Original languageEnglish
    Article number611
    JournalFrontiers in Immunology
    Volume5
    Issue numberArticle 611
    DOIs
    Publication statusPublished - 2014

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