The role of ondansetron in the management of cholestatic or uremic pruritus - A systematic review

Timothy To, Katherine Clark, L Lam, Tania Shelby-James, David Currow

    Research output: Contribution to journalReview articlepeer-review

    19 Citations (Scopus)

    Abstract

    Context: Pruritus associated with hepatic or renal failure can be a troublesome symptom, refractory to treatment and associated with significant physical and emotional distress and a reduction in quality of life for patients already burdened with chronic disease. Serotonin has been implicated as a possible pathological mediator, and, therefore, 5HT3 antagonists have been suggested as a possible therapeutic intervention. Objectives: This review of the literature systematically explores the role of ondansetron in the management of cholestatic or uremic pruritus. Methods: Electronic databases were systematically searched for randomized controlled trials examining the role of ondansetron in cholestatic or uremic pruritus between 1966 and 2008. Results: Five randomized controlled trials were included in this systematic review: three for cholestatic pruritus and two for uremic pruritus. All trials examined ondansetron vs. placebo, with differing treatment protocols. Overall, three studies showed no benefit to ondansetron over placebo; however, two studies in cholestatic pruritus showed small reductions in pruritus with questionable clinical significance. Conclusion: Ondansetron was demonstrated to have negligible effect on cholestatic or uremic pruritus on the basis of a limited number of studies.

    Original languageEnglish
    Pages (from-to)725-730
    Number of pages6
    JournalJournal of Pain and Symptom Management
    Volume44
    Issue number5
    DOIs
    Publication statusPublished - Nov 2012

    Keywords

    • 5HT antagonists
    • cholestasis
    • hepatic failure
    • itch
    • Ondansetron
    • pruritus
    • renal failure
    • uremia

    Fingerprint

    Dive into the research topics of 'The role of ondansetron in the management of cholestatic or uremic pruritus - A systematic review'. Together they form a unique fingerprint.

    Cite this