The Role of the Neuroprotective Factor Npas4 in Cerebral Ischemia

Fong Choy, Thomas Klaric, Simon Koblar, Martin Lewis

    Research output: Contribution to journalReview articlepeer-review

    26 Citations (Scopus)


    Stroke is one of the leading causes of death and adult disability in the world. Although many molecules have been documented to have a neuroprotective effect, the majority of these molecules failed to improve the neurological outcomes for patients with brain ischemia. It has been proposed that neuroprotection alone may, in fact, not be adequate for improving the prognosis of ischemic stroke. Neuroprotectants that can regulate other processes which occur in the brain during ischemia could potentially be targets for the development of effective therapeutic interventions in stroke. Neuronal Per-Arnt-Sim domain protein 4 (Npas4) is an activity-dependent transcription factor whose expression is induced in various brain insults, including cerebral ischemia. It has been shown that Npas4 plays an important role in protecting neurons against many types of neurodegenerative insult. Recently, it was demonstrated that Npas4 indeed has a neuroprotective role in ischemic stroke and that Npas4 might be involved in modulating the cell death pathway and inflammatory response. In this review, we summarize the current knowledge of the roles that Npas4 may play in neuroinflammation and ischemia. Understanding how ischemic lesion size in stroke may be reduced through modulation of Npas4-dependent apoptotic and inflammatory pathways could lead to the development of new stroke therapies.

    Original languageEnglish
    Pages (from-to)29011-29028
    Number of pages18
    JournalInternational Journal of Molecular Sciences
    Issue number12
    Publication statusPublished - 2015


    • Apoptosis
    • Ischemic stroke
    • Neuroinflammation
    • Neuroprotection
    • Npas4


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