The role played by drug efflux pumps in bacterial multidrug resistance

Mohsen Chitsaz, Melissa H. Brown

    Research output: Contribution to journalReview article

    23 Citations (Scopus)

    Abstract

    Antimicrobial resistance is a current major challenge in chemotherapy and infection control. The ability of bacterial and eukaryotic cells to recognize and pump toxic compounds from within the cell to the environment before they reach their targets is one of the important mechanisms contributing to this phenomenon. Drug efflux pumps are membrane transport proteins that require energy to export substrates and can be selective for a specific drug or poly-specific that can export multiple structurally diverse drug compounds. These proteins can be classified into seven groups based on protein sequence homology, energy source and overall structure. Extensive studies on efflux proteins have resulted in a wealth of knowledge that has made possible in-depth understanding of the structures and mechanisms of action, substrate profiles, regulation and possible inhibition of many clinically important efflux pumps. This review focuses on describing known families of drug efflux pumps using examples that are well characterized structurally and/or biochemically.

    Original languageEnglish
    Pages (from-to)127-139
    Number of pages13
    JournalEssays in Biochemistry
    Volume61
    Issue number1
    DOIs
    Publication statusPublished - 3 Mar 2017

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