TY - JOUR
T1 - The scent of love is in the air(way)
T2 - a potential drug target for sleep apnea?
AU - Osman, Amal M.
AU - Altree, Thomas J.
AU - Eckert, Danny J.
PY - 2023/4
Y1 - 2023/4
N2 - Fundamentally, obstructive sleep apnea (OSA) is characterized by the interaction between impaired pharyngeal anatomy and inadequate dilator muscle function during sleep [1]. Accordingly, strategies to reactivate upper airway dilator muscle activity during sleep are a key target for emerging pharmacotherapy for OSA [1–7]. Indeed, several preclinical, e.g. [8–12] and translational clinical proof of concept findings e.g. [2, 5, 6, 13–18] show considerable promise for the development of OSA pharmacotherapy.
AB - Fundamentally, obstructive sleep apnea (OSA) is characterized by the interaction between impaired pharyngeal anatomy and inadequate dilator muscle function during sleep [1]. Accordingly, strategies to reactivate upper airway dilator muscle activity during sleep are a key target for emerging pharmacotherapy for OSA [1–7]. Indeed, several preclinical, e.g. [8–12] and translational clinical proof of concept findings e.g. [2, 5, 6, 13–18] show considerable promise for the development of OSA pharmacotherapy.
KW - obstructive sleep apnea (OSA)
KW - OSA pharmacotherapy
KW - sleep disordered breathing
UR - http://www.scopus.com/inward/record.url?scp=85152244700&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/NHMRC/1196261
U2 - 10.1093/sleep/zsad019
DO - 10.1093/sleep/zsad019
M3 - Editorial
C2 - 36719095
AN - SCOPUS:85152244700
SN - 0161-8105
VL - 46
SP - 1
EP - 4
JO - SLEEP
JF - SLEEP
IS - 4
ER -