The search for electrophysiological biomarkers of vigilance failure in OSA

    Research output: Contribution to journalMeeting Abstractpeer-review


    Obstructive sleep apnoea (OSA) is rising in prevalence and is linked
    with driving impairment and elevated risk motor vehicle accidents
    (MVA). However, daytime sleepiness and neurobehavioral/vigilance
    impairment varies markedly between OSA patients. Accident risk may
    be confined to a subset of patients who are more susceptible to vigilance
    failure. Identification of OSA patients at risk of vigilance failure and
    MVAs is critical but currently challenging since routine clinical metrics
    of OSA severity and sleepiness have poor predictive value. New
    neurobehavioral and electrophysiological tests/measures are needed to
    more accurately identify the “sleepy” OSA phenotype. Ideally these tests
    need to be simple, inexpensive and clinically deployable.
    Currently the EEG and ECG signals routinely collected during overnight
    sleep studies are only superficially analysed by manual scoring,
    potentially missing a lot of disease specific effects on the brain. Quantitative
    power spectral analysis automatically quantifies these signals at
    much higher resolution allowing for detection of specific spectral frequency
    signatures that may help to explain the variation in
    neurobehavioral function and the risk of vigilance failure on OSA.
    Previous small studies from our group suggest spectral EEG markers
    derived from sleep and wake EEG, as well as evoked related potentials
    (ERPs) correlate with driving simulator impairment in OSA patients
    following extended wakefulness. There also appears to be a phenotypic
    difference in heart rate variability (HRV) in healthy subjects who are
    vulnerable vs resistant to sleep loss. These findings will be presented and discussed and future OSA neurobehavioral and electrophysiological
    phenotyping approaches discussed. Future laboratory based and large
    accident risk validation studies will be crucial before useful markers of
    vigilance failure are translated into routine clinical practice.
    Original languageEnglish
    Article number145
    Pages (from-to)50-51
    Number of pages2
    JournalSleep and Biological Rhythms
    Issue numberS1
    Publication statusPublished - Oct 2015
    EventSleep Down Under 2015 Cycles - Melbourne, Australia
    Duration: 22 Oct 201524 Oct 2015
    Conference number: 27th


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