The source of the nerve fibres forming the deep muscular and circular muscle plexuses in the small intestine of the guinea-pig

A. J. Wilson, I. J. Llewellyn-Smith, J. B. Furness, M. Costa

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

A quantitative ultrastructural study was made of the neuntes forming the deep muscular and circular muscle plexuses of the guinea-pig small intestine following microsurgical lesions designed to interrupt intrinsic and extrinsic nerve pathways within the intestinal wall. Removal of a collar of longitudinal muscle with attached myenteric plexus from the circumference of a segment of small intestine resulted in the subsequent disappearance of 99.3% of neurites in the underlying circular muscle. The few surviving neurites in the deep muscular plexus and circular muscle disappeared completely from lesioned segments that were, in addition, extrinsically denervated surgically. These results indicate that the majority of nerve fibres in the deep muscular and circular muscle plexuses of the guinea-pig small intestine is intrinsic to the intestine and originates from nerve cell bodies located in the overlying myenteric plexus. At the light-microscopic level, nerve bundles were traced from the myenteric plexus to the circular muscle.

Original languageEnglish
Pages (from-to)497-504
Number of pages8
JournalCell and Tissue Research
Volume247
Issue number3
DOIs
Publication statusPublished - 1 Mar 1987

Keywords

  • Enteric nervous system
  • Guinea-pig
  • Intestine, small
  • Nerves, degeneration
  • Neuronal connections

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