The synovium

Malcolm D. Smith, Mihir D. Wechalekar

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

7 Citations (Scopus)


Synovium is the soft tissue lining the spaces of diarthrodial joints, tendon sheaths, and bursae. The term includes both the continuous surface layer of cells (intima) and the underlying tissue (subintima). The intima is com-posed of specialized macrophages and fibroblasts, and the subintima con-tains blood and lymphatic vessels, a cellular content of both resident fibroblasts and infiltrating cells in a collagenous extracellular matrix. Between the intimal surfaces is a small amount of fluid, usually rich in hyaluronan (hyaluronic acid). Together, this structure provides a nonadher-ent surface between tissue elements. Unlike serosal surfaces, which also have nonadherent properties, synovium is derived from ectoderm and does not contain a basal lamina.
Original languageEnglish
Title of host publicationRheumatology
Subtitle of host publicationSixth Edition
PublisherElsevier Inc.
Number of pages6
ISBN (Electronic)9780323325851
ISBN (Print)9780323091381
Publication statusPublished - 2015
Externally publishedYes


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