The synthesis and investigation of impurities found in Clandestine Laboratories: Baeyer–Villiger Route Part I; Synthesis of P2P from benzaldehyde and methyl ethyl ketone

David Doughty, Benjamin Painter, Paul Pigou, Martin Johnston

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    The synthesis of impurities detected in clandestinely manufactured Amphetamine Type Stimulants (ATS) has emerged as more desirable than simple "fingerprint" profiling. We have been investigating the impurities formed when phenyl-2-propanone (P2P) 5, a key ATS precursor, is synthesised in three steps; an aldol condensation of benzaldehyde and methyl ethyl ketone (MEK); a Baeyer-Villiger reaction; and ester hydrolysis. We have identified and selectively synthesised several impurities that may be used as route specific markers for this series of synthetic steps. Specifically these impurities are 3-methyl-4-phenyl-3-buten-2-one 3, 2-methyl-1,5-diphenylpenta-1,4-diene-3-one 9, 2-(methylamino)-3-methyl-4-phenyl-3-butene 16, 2-(Methylamino)-3-methyl-4-phenylbutane 17, and 1-(methylamino)-2-methyl-1,5-diphenylpenta-4-ene-3-one 22.

    Original languageEnglish
    Pages (from-to)55-66
    Number of pages12
    JournalForensic Science International
    Volume263
    DOIs
    Publication statusPublished - 1 Jun 2016

    Keywords

    • Baeyer-villiger reaction
    • Clandestine synthesis
    • Methamphetamine
    • P2P

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