The synthesis of di-carboxylate esters using continuous flow vortex fluidics

Joshua Britton, Stuart Dalziel, Colin Raston

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    A vortex fluidic device (VFD) is effective in mediating the synthesis of di-esters at room temperature. Processing under ambient conditions allows for a simple and efficient synthesis, whilst operating under continuous flow addresses scalability. The rotational speed of the sample tube and the flow rate were critical variables during reaction optimization, and this relates to the behaviour of the fluid flow at a molecular level. Whilst at specific rotational speeds the tube imparts a vibrational response into the fluid flow, the flow rate dictates residence time and the ability to maintain high levels of shear stress. The combination of mechanically induced vibrations, rapid micromixing, high levels of shear stress and water evaporation results in yields up to 90% for 3.25 minutes or less residence time. These results are key for devising greener and more efficient processes both mediated by the VFD and other continuous flow platforms.

    Original languageEnglish
    Pages (from-to)2193-2200
    Number of pages8
    JournalGreen Chemistry
    Volume18
    Issue number7
    DOIs
    Publication statusPublished - 2016

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