The synthesis of (R)-(-) and (S)-(+)-hydroxysaclofen

Rolf H Prager; Karl Schafer; David P G Hamon; Ralph A Massy-Westropp

doi:10.1016/0040-4020(95)00710-P

The synthesis of (R)-(-) and (S)-(+)-hydroxysaclofen

Rolf H Prager
, Karl Schafer
, David P G Hamon
, Ralph A Massy-Westropp

College of Science and Engineering

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

2-(4-Chlorophenyl)-3-hydroxypropene has been separately converted to both enantiomers of its epoxide. The epoxides were converted to (R)-(-) and (S)-(+)-hydroxysaclofen. Only the latter showed activity as a specific GABA_B antagonist.

Original language	English
Pages (from-to)	11465-11472
Number of pages	8
Journal	Tetrahedron
Volume	51
Issue number	42
DOIs	https://doi.org/10.1016/0040-4020(95)00710-P
Publication status	Published - 16 Oct 1995

Access to Document

10.1016/0040-4020(95)00710-PLicence: In Copyright

Cite this

@article{deb9b8ad47604e898ba9738243ed9d19,

title = "The synthesis of (R)-(-) and (S)-(+)-hydroxysaclofen",

abstract = "2-(4-Chlorophenyl)-3-hydroxypropene has been separately converted to both enantiomers of its epoxide. The epoxides were converted to (R)-(-) and (S)-(+)-hydroxysaclofen. Only the latter showed activity as a specific GABAB antagonist.",

author = "Prager, \{Rolf H\} and Karl Schafer and Hamon, \{David P G\} and Massy-Westropp, \{Ralph A\}",

year = "1995",

month = oct,

day = "16",

doi = "10.1016/0040-4020(95)00710-P",

language = "English",

volume = "51",

pages = "11465--11472",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd.",

number = "42",

}

TY - JOUR

T1 - The synthesis of (R)-(-) and (S)-(+)-hydroxysaclofen

AU - Prager, Rolf H

AU - Schafer, Karl

AU - Hamon, David P G

AU - Massy-Westropp, Ralph A

PY - 1995/10/16

Y1 - 1995/10/16

N2 - 2-(4-Chlorophenyl)-3-hydroxypropene has been separately converted to both enantiomers of its epoxide. The epoxides were converted to (R)-(-) and (S)-(+)-hydroxysaclofen. Only the latter showed activity as a specific GABAB antagonist.

AB - 2-(4-Chlorophenyl)-3-hydroxypropene has been separately converted to both enantiomers of its epoxide. The epoxides were converted to (R)-(-) and (S)-(+)-hydroxysaclofen. Only the latter showed activity as a specific GABAB antagonist.

UR - https://www.scopus.com/pages/publications/0029151755

U2 - 10.1016/0040-4020(95)00710-P

DO - 10.1016/0040-4020(95)00710-P

M3 - Article

AN - SCOPUS:0029151755

SN - 0040-4020

VL - 51

SP - 11465

EP - 11472

JO - Tetrahedron

JF - Tetrahedron

IS - 42

ER -

The synthesis of (R)-(-) and (S)-(+)-hydroxysaclofen

Abstract

Access to Document

Other files and links

Fingerprint

Cite this