The transcriptional landscape of the mammalian genome

The FANTOM Consortium

    Research output: Contribution to journalArticle

    2428 Citations (Scopus)

    Abstract

    This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5′ and 3′ boundaries of 181.047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.

    Original languageEnglish
    Pages (from-to)1559-1563
    Number of pages5
    JournalScience
    Volume309
    Issue number5740
    DOIs
    Publication statusPublished - 2 Sep 2005

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