Abstract
Key points
The use of regular, low-dose morphine to reduce symptomatic chronic breathlessness was identified in a systematic review and meta-analysis.
Since that meta-analysis, three adequately powered studies have not confirmed its findings in people with moderate to severe chronic breathlessness.
Two of those subsequent studies identified that people with COPD and severe breathlessness (housebound or breathless when dressing or undressing) may derive symptomatic benefits safely.
A short trial (1 week) of regular, low-dose, sustained-release morphine (10 mg/24 h) can be considered in such patients.
The use of regular, low-dose morphine to reduce symptomatic chronic breathlessness was identified in a systematic review and meta-analysis.
Since that meta-analysis, three adequately powered studies have not confirmed its findings in people with moderate to severe chronic breathlessness.
Two of those subsequent studies identified that people with COPD and severe breathlessness (housebound or breathless when dressing or undressing) may derive symptomatic benefits safely.
A short trial (1 week) of regular, low-dose, sustained-release morphine (10 mg/24 h) can be considered in such patients.
| Original language | English |
|---|---|
| Pages (from-to) | 1017-1019 |
| Number of pages | 3 |
| Journal | Respirology |
| Volume | 29 |
| Issue number | 12 |
| Early online date | 7 Oct 2024 |
| DOIs |
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| Publication status | Published - Dec 2024 |
Keywords
- chronic obstructive pulmonary disease
- COPD
- meta-analysis