Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: An Australian and New Zealand perspective Part 2 New and emerging therapies and their efficacy

Simon Broadley, Michael Barnett, Mike Boggild, Bruce Brew, H Butzkueven, Robert Heard, Suzanne Hodgkinson, Allan Kermode, Jeannette Lechner-Scott, Richard Macdonell, Mark Marriott, Deborah Mason, John Parratt, Stephen Reddel, Cameron Shaw, Mark Slee, Judith Spies, Bruce Taylor, William Carroll, Trevor KilpatrickJohn King, Pamela McCombe, John Pollard, Ernie Willoughby

    Research output: Contribution to journalReview articlepeer-review

    15 Citations (Scopus)

    Abstract

    In Part 2 of this three part review of multiple sclerosis (MS) treatment with a particular focus on the Australian and New Zealand perspective, we review the newer therapies that have recently become available and emerging therapies that have now completed phase III clinical trial programs. We go on to compare the relative efficacies of these newer and emerging therapies alongside the existing therapies. The effectiveness of β-interferon in the treatment of different stages and the different disease courses of MS is critically reviewed with the conclusion that the absolute level of response in term of annualised relapse rates (where relapses occur) and MRI activity are similar, but are disappointing in terms of sustained disability progression for progressive forms of the disease. Finally we review the controversial area of combination therapy for MS. Whilst it remains the case that we have no cure or means of preventing MS, we do have a range of effective therapies that when used appropriately and early in the disease course can have a significant impact on short term and longer term outcomes.

    Original languageEnglish
    Pages (from-to)1847-1856
    Number of pages10
    JournalJournal of Clinical Neuroscience
    Volume21
    Issue number11
    DOIs
    Publication statusPublished - 1 Nov 2014

    Keywords

    • Evidence-based medicine
    • Guideline
    • Multiple sclerosis
    • Review
    • Treatment

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