Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: an Australian and New Zealand perspective part 1 historical and established therapies

Simon Broadley, Michael Barnett, Mike Boggild, Bruce Brew, H Butzkueven, Robert Heard, Suzanne Hodgkinson, Allan Kermode, Jeannette Lechner-Scott, Richard Macdonell, Mark Marriott, Deborah Mason, John Parratt, Stephen Reddel, Cameron Shaw, Mark Slee, Judith Spies, Bruce Taylor, William Carroll, Trevor KilpatrickJohn King, Pamela McCombe, John Pollard, Ernie Willoughby

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)

    Abstract

    Multiple sclerosis (MS) is a potentially life-changing immune mediated disease of the central nervous system. Until recently, treatment has been largely confined to acute treatment of relapses, symptomatic therapies and rehabilitation. Through persistent efforts of dedicated physicians and scientists around the globe for 160 years, a number of therapies that have an impact on the long term outcome of the disease have emerged over the past 20 years. In this three part series we review the practicalities, benefits and potential hazards of each of the currently available and emerging treatment options for MS. We pay particular attention to ways of abrogating the risks of these therapies and provide advice on the most appropriate indications for using individual therapies. In Part 1 we review the history of the development of MS therapies and its connection with the underlying immunobiology of the disease. The established therapies for MS are reviewed in detail and their current availability and indications in Australia and New Zealand are summarised. We examine the evidence to support their use in the treatment of MS.

    Original languageEnglish
    Pages (from-to)1835-1846
    Number of pages12
    JournalJournal of Clinical Neuroscience
    Volume21
    Issue number11
    DOIs
    Publication statusPublished - 2014

    Fingerprint Dive into the research topics of 'Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: an Australian and New Zealand perspective part 1 historical and established therapies'. Together they form a unique fingerprint.

    Cite this