Thermolabile phenol sulfotransferase gene (stm): Localization to human chromosome 16p11.2

Ibrahim A. Aksoy; David F. Callen; Sinoula Apostolou; Chengtao Her; Richard M. Weinshilboum

doi:10.1006/geno.1994.1494

Thermolabile phenol sulfotransferase gene (stm): Localization to human chromosome 16p11.2

Ibrahim A. Aksoy
, David F. Callen
, Sinoula Apostolou
, Chengtao Her
, Richard M. Weinshilboum

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Thermolabile (TL) phenol sulfotransferase (PST) catalyzes the sulfate conjugation of phenolic monoamine neurotransmitters such as dopamine and serotonin. We recently cloned a cDNA for human liver TL PST and expressed it in COS-1 cells. We now report the chromosomal localization of the human TL PST gene (STM) as well as its partial sequence. DNA from NIGMS Human/Rodent Somatic Cell Hybrid Mapping Panels 1 and 2 was screened by use of the PCR, and the STM gene was mapped to chromosome 16. Regional localization to 16p11.2 was performed by PCR analysis of a high-resolution mouse/human somatic cell hybrid panel that contained defined portions of human chromosome 16.

Original language	English
Pages (from-to)	275-277
Number of pages	3
Journal	Genomics
Volume	23
Issue number	1
DOIs	https://doi.org/10.1006/geno.1994.1494
Publication status	Published - 1 Sept 1994
Externally published	Yes

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title = "Thermolabile phenol sulfotransferase gene (stm): Localization to human chromosome 16p11.2",

abstract = "Thermolabile (TL) phenol sulfotransferase (PST) catalyzes the sulfate conjugation of phenolic monoamine neurotransmitters such as dopamine and serotonin. We recently cloned a cDNA for human liver TL PST and expressed it in COS-1 cells. We now report the chromosomal localization of the human TL PST gene (STM) as well as its partial sequence. DNA from NIGMS Human/Rodent Somatic Cell Hybrid Mapping Panels 1 and 2 was screened by use of the PCR, and the STM gene was mapped to chromosome 16. Regional localization to 16p11.2 was performed by PCR analysis of a high-resolution mouse/human somatic cell hybrid panel that contained defined portions of human chromosome 16.",

author = "Aksoy, \{Ibrahim A.\} and Callen, \{David F.\} and Sinoula Apostolou and Chengtao Her and Weinshilboum, \{Richard M.\}",

year = "1994",

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doi = "10.1006/geno.1994.1494",

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T1 - Thermolabile phenol sulfotransferase gene (stm)

T2 - Localization to human chromosome 16p11.2

AU - Aksoy, Ibrahim A.

AU - Callen, David F.

AU - Apostolou, Sinoula

AU - Her, Chengtao

AU - Weinshilboum, Richard M.

PY - 1994/9/1

Y1 - 1994/9/1

N2 - Thermolabile (TL) phenol sulfotransferase (PST) catalyzes the sulfate conjugation of phenolic monoamine neurotransmitters such as dopamine and serotonin. We recently cloned a cDNA for human liver TL PST and expressed it in COS-1 cells. We now report the chromosomal localization of the human TL PST gene (STM) as well as its partial sequence. DNA from NIGMS Human/Rodent Somatic Cell Hybrid Mapping Panels 1 and 2 was screened by use of the PCR, and the STM gene was mapped to chromosome 16. Regional localization to 16p11.2 was performed by PCR analysis of a high-resolution mouse/human somatic cell hybrid panel that contained defined portions of human chromosome 16.

AB - Thermolabile (TL) phenol sulfotransferase (PST) catalyzes the sulfate conjugation of phenolic monoamine neurotransmitters such as dopamine and serotonin. We recently cloned a cDNA for human liver TL PST and expressed it in COS-1 cells. We now report the chromosomal localization of the human TL PST gene (STM) as well as its partial sequence. DNA from NIGMS Human/Rodent Somatic Cell Hybrid Mapping Panels 1 and 2 was screened by use of the PCR, and the STM gene was mapped to chromosome 16. Regional localization to 16p11.2 was performed by PCR analysis of a high-resolution mouse/human somatic cell hybrid panel that contained defined portions of human chromosome 16.

UR - https://www.scopus.com/pages/publications/0028101442

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DO - 10.1006/geno.1994.1494

M3 - Article

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AN - SCOPUS:0028101442

SN - 0888-7543

VL - 23

SP - 275

EP - 277

JO - Genomics

JF - Genomics

IS - 1

ER -

Thermolabile phenol sulfotransferase gene (stm): Localization to human chromosome 16p11.2

Abstract

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