Thrombokinetics in patients with rheumatoid arthritis treated with D-penicillamine

D. Thomas; A. S. Gallus; P. M. Brooks; R. Tampi; R. Geddes; W. Hill

doi:10.1136/ard.43.3.402

Thrombokinetics in patients with rheumatoid arthritis treated with D-penicillamine

D. Thomas, A. S. Gallus, P. M. Brooks, R. Tampi, R. Geddes, W. Hill

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Abstract

The mechanism of D-penicillamine induced thrombocytopenia in rheumatoid arthritis was investigated by measuring platelet life-span and platelet production rate in 2 groups of rheumatoid arthritis patients treated with 250-750 mg/day D-penicillamine, 14 with a normal platelet count and 9 with thrombocytopenia (platelet count 50-130 x 10⁹/l). Age matched control patients not treated with D-penicillamine included 14 with rheumatoid arthritis and 9 with osteoarthritis. The platelet life-span was normal, but platelet production rate was significantly reduced in the thrombocytopenic patients, suggesting that D-penicillamine causes thrombocytopenia through bone marrow suppression.

Original language	English
Pages (from-to)	402-406
Number of pages	5
Journal	Annals of the Rheumatic Diseases
Volume	43
Issue number	3
DOIs	https://doi.org/10.1136/ard.43.3.402
Publication status	Published - 1984

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AU - Tampi, R.

AU - Geddes, R.

AU - Hill, W.

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N2 - The mechanism of D-penicillamine induced thrombocytopenia in rheumatoid arthritis was investigated by measuring platelet life-span and platelet production rate in 2 groups of rheumatoid arthritis patients treated with 250-750 mg/day D-penicillamine, 14 with a normal platelet count and 9 with thrombocytopenia (platelet count 50-130 x 109/l). Age matched control patients not treated with D-penicillamine included 14 with rheumatoid arthritis and 9 with osteoarthritis. The platelet life-span was normal, but platelet production rate was significantly reduced in the thrombocytopenic patients, suggesting that D-penicillamine causes thrombocytopenia through bone marrow suppression.

AB - The mechanism of D-penicillamine induced thrombocytopenia in rheumatoid arthritis was investigated by measuring platelet life-span and platelet production rate in 2 groups of rheumatoid arthritis patients treated with 250-750 mg/day D-penicillamine, 14 with a normal platelet count and 9 with thrombocytopenia (platelet count 50-130 x 109/l). Age matched control patients not treated with D-penicillamine included 14 with rheumatoid arthritis and 9 with osteoarthritis. The platelet life-span was normal, but platelet production rate was significantly reduced in the thrombocytopenic patients, suggesting that D-penicillamine causes thrombocytopenia through bone marrow suppression.

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JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

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ER -

Thrombokinetics in patients with rheumatoid arthritis treated with D-penicillamine

Abstract

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