Thrombokinetics in patients with rheumatoid arthritis treated with D-penicillamine

D. Thomas, A. S. Gallus, P. M. Brooks, R. Tampi, R. Geddes, W. Hill

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)


    The mechanism of D-penicillamine induced thrombocytopenia in rheumatoid arthritis was investigated by measuring platelet life-span and platelet production rate in 2 groups of rheumatoid arthritis patients treated with 250-750 mg/day D-penicillamine, 14 with a normal platelet count and 9 with thrombocytopenia (platelet count 50-130 x 109/l). Age matched control patients not treated with D-penicillamine included 14 with rheumatoid arthritis and 9 with osteoarthritis. The platelet life-span was normal, but platelet production rate was significantly reduced in the thrombocytopenic patients, suggesting that D-penicillamine causes thrombocytopenia through bone marrow suppression.

    Original languageEnglish
    Pages (from-to)402-406
    Number of pages5
    JournalAnnals of the Rheumatic Diseases
    Issue number3
    Publication statusPublished - 1984


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