TY - JOUR
T1 - Thrombolysis for acute stroke in Australia: outcomes from the Safe Implementation of Thrombolysis in Stroke registry (2002-2008)
AU - Simpson, Marian
AU - Dewey, Helen
AU - Churilov, Leonid
AU - Ahmed, Niaz
AU - Bladin, C
AU - Schultz, David
AU - Markus, Romesh
AU - Sturm, J
AU - Levi, C
AU - Blacker, David
AU - Jannes, J
AU - Lindley, Richard
AU - Parsons, M
PY - 2010/10/18
Y1 - 2010/10/18
N2 - Objective: To report Australian outcomes from the Safe Implementation of Thrombolysis in Stroke International Stroke Thrombolysis Register (SITS-ISTR). Design: Observational study using data collected prospectively from December 2002 to December 2008. Setting: Centres administering thrombolysis for acute stroke in Australia and worldwide. Patients: All patients treated with recombinant tissue plasminogen activator for acute stroke in participating centres, regardless of stroke severity, time of treatment and other clinical factors. Intervention: Thrombolysis for acute stroke, administered according to local protocol. Main outcome measures: Functional outcome as 3-month modified Rankin score (mRS), and frequency of symptomatic intracerebral haemorrhage (ICH). Results: During the study period, a total of 32 countries participated, and confirmed baseline data were available for 581 Australian patients and 20953 patients in the rest of the world. Australian patients were older (median age, 73 v 69 years; P<0.001), were less independent before stroke (premorbid mRS of 0-1, 87.5% v 91.2%; P<0.005), and had more comorbidities and more severe strokes. Comparing the Australian cohort with the rest of the world, the odds ratio of 3-month mRS of 0-2 was 0.98 (95% CI, 0.88-1.08; P=0.63), the odds ratio of symptomatic ICH was 0.98 (95% CI, 0.83-1.16; P=0.85 [by the definition used by the National Institute of Neurological Disorders]) and the odds ratio of death was 1.04 (95% CI, 0.91-1.19; P=0.54). Good outcome in the Australian cohort was predicted by younger age, presence of hyperlipidaemia, lower premorbid mRS, absence of infarct on early brain imaging, less severe stroke, and lower baseline blood glucose level. Conclusion: Clinical outcomes after thrombolysis in Australia were similar to those worldwide.
AB - Objective: To report Australian outcomes from the Safe Implementation of Thrombolysis in Stroke International Stroke Thrombolysis Register (SITS-ISTR). Design: Observational study using data collected prospectively from December 2002 to December 2008. Setting: Centres administering thrombolysis for acute stroke in Australia and worldwide. Patients: All patients treated with recombinant tissue plasminogen activator for acute stroke in participating centres, regardless of stroke severity, time of treatment and other clinical factors. Intervention: Thrombolysis for acute stroke, administered according to local protocol. Main outcome measures: Functional outcome as 3-month modified Rankin score (mRS), and frequency of symptomatic intracerebral haemorrhage (ICH). Results: During the study period, a total of 32 countries participated, and confirmed baseline data were available for 581 Australian patients and 20953 patients in the rest of the world. Australian patients were older (median age, 73 v 69 years; P<0.001), were less independent before stroke (premorbid mRS of 0-1, 87.5% v 91.2%; P<0.005), and had more comorbidities and more severe strokes. Comparing the Australian cohort with the rest of the world, the odds ratio of 3-month mRS of 0-2 was 0.98 (95% CI, 0.88-1.08; P=0.63), the odds ratio of symptomatic ICH was 0.98 (95% CI, 0.83-1.16; P=0.85 [by the definition used by the National Institute of Neurological Disorders]) and the odds ratio of death was 1.04 (95% CI, 0.91-1.19; P=0.54). Good outcome in the Australian cohort was predicted by younger age, presence of hyperlipidaemia, lower premorbid mRS, absence of infarct on early brain imaging, less severe stroke, and lower baseline blood glucose level. Conclusion: Clinical outcomes after thrombolysis in Australia were similar to those worldwide.
UR - http://www.scopus.com/inward/record.url?scp=78149336330&partnerID=8YFLogxK
U2 - 10.5694/j.1326-5377.2010.tb03996.x
DO - 10.5694/j.1326-5377.2010.tb03996.x
M3 - Article
VL - 193
SP - 439
EP - 443
JO - Medical Journal of Australia
JF - Medical Journal of Australia
SN - 0025-729X
IS - 8
ER -