TY - JOUR
T1 - "Thunderstruck"
T2 - Plasma-Polymer-Coated Porous Silicon Microparticles As a Controlled Drug Delivery System
AU - McInnes, Steven J.P.
AU - Michl, Thomas D.
AU - Delalat, Bahman
AU - Al-Bataineh, Sameer A.
AU - Coad, Bryan R.
AU - Vasilev, Krasimir
AU - Griesser, Hans J.
AU - Voelcker, Nicolas H.
PY - 2016/2/24
Y1 - 2016/2/24
N2 - Controlling the release kinetics from a drug carrier is crucial to maintain a drug"s therapeutic window. We report the use of biodegradable porous silicon microparticles (pSi MPs) loaded with the anticancer drug camphothecin, followed by a plasma polymer overcoating using a loudspeaker plasma reactor. Homogenous "Teflon-like" coatings were achieved by tumbling the particles by playing AC/DC"s song "Thunderstruck". The overcoating resulted in a markedly slower release of the cytotoxic drug, and this effect correlated positively with the plasma polymer coating times, ranging from 2-fold up to more than 100-fold. Ultimately, upon characterizing and verifying pSi MP production, loading, and coating with analytical methods such as time-of-flight secondary ion mass spectrometry, scanning electron microscopy, thermal gravimetry, water contact angle measurements, and fluorescence microscopy, human neuroblastoma cells were challenged with pSi MPs in an in vitro assay, revealing a significant time delay in cell death onset.
AB - Controlling the release kinetics from a drug carrier is crucial to maintain a drug"s therapeutic window. We report the use of biodegradable porous silicon microparticles (pSi MPs) loaded with the anticancer drug camphothecin, followed by a plasma polymer overcoating using a loudspeaker plasma reactor. Homogenous "Teflon-like" coatings were achieved by tumbling the particles by playing AC/DC"s song "Thunderstruck". The overcoating resulted in a markedly slower release of the cytotoxic drug, and this effect correlated positively with the plasma polymer coating times, ranging from 2-fold up to more than 100-fold. Ultimately, upon characterizing and verifying pSi MP production, loading, and coating with analytical methods such as time-of-flight secondary ion mass spectrometry, scanning electron microscopy, thermal gravimetry, water contact angle measurements, and fluorescence microscopy, human neuroblastoma cells were challenged with pSi MPs in an in vitro assay, revealing a significant time delay in cell death onset.
KW - controlled drug release
KW - fluorinated coating
KW - particle coating
KW - plasma polymerization
KW - porous silicon
UR - http://www.scopus.com/inward/record.url?scp=84961572685&partnerID=8YFLogxK
U2 - 10.1021/acsami.5b12433
DO - 10.1021/acsami.5b12433
M3 - Article
C2 - 26836366
AN - SCOPUS:84961572685
SN - 1944-8244
VL - 8
SP - 4467
EP - 4476
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 7
ER -