Tibial cartilage, subchondral bone plate and bone microarchiteture in varus- and valgus-OA vs. controls

Sophie Rapagna, Bryant Roberts, Lucian Solomon, Haoqian Qian, Karen Reynolds, Dominic Thewlis, Egon Perilli

Research output: Contribution to conferencePaper

Abstract

In knee osteoarthritis (OA), regional changes in proximal tibia subchondral bone plate (SBP), subchondral trabecular bone (STB) and cartilage may reflect joint loading [1, 2]. However, reports on STB and SBP differences between OA and non-pathological joints are conflicting [3, 4]. Moreover, the effect of joint alignment on cartilage morphology (thickness), the SBP and underlying STB remains unexplored [1]. This analysis aims to quantify tibia cartilage thickness, SBP thickness and STB microarchitecture in end-stage knee OA patients with varus- or valgus-aligned joints, comparing them to control (non-OA) knees.

Original languageEnglish
Pages436
Number of pages1
Publication statusPublished - Jul 2019
Event25th Congress of the European Society of Biomechanics, 2019 - Vienna, Austria
Duration: 7 Jul 201910 Jul 2019
Conference number: 25
https://esbiomech.org/conference/esb2019/ (Conference link)

Conference

Conference25th Congress of the European Society of Biomechanics, 2019
Abbreviated titleESB 2019
CountryAustria
CityVienna
Period7/07/1910/07/19
OtherAt TU Wien itself, biomechanical activities date back at least to the late 1980s and early 1990s, arising from interactions between groups from TU Wien’s Mechanical and Civil Engineering Departments and the Viennese Medical institutions. They comprise pioneering forms of bone micromechanics and adaptation modelling at the then Institute of Lightweight Design and Aerospace Engineering, or the first-ever testing device for anisotropic elasticity testing of skin, at the then Institute for Strength of Materials. In 2003, the first professor of biomechanics was appointed at TU Wien who not only established a working group in this area, but also founded the Interfacultary Laboratory for Micro- and Nanomechanics of Biological and Biomimetical Materials.
Internet address

Keywords

  • knee osteoarthritis
  • tibia subchondral bone plate (SBP)
  • tibia cartilage thickness

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    Rapagna, S., Roberts, B., Solomon, L., Qian, H., Reynolds, K., Thewlis, D., & Perilli, E. (2019). Tibial cartilage, subchondral bone plate and bone microarchiteture in varus- and valgus-OA vs. controls. 436. Paper presented at 25th Congress of the European Society of Biomechanics, 2019, Vienna, Austria.