Timing of cardiovascular magnetic resonance in clinical trials evaluating cardioprotective therapies to reduce infarct size

Joseph B. Selvanayagam, Rajiv Ananthakrishna, Cheerag Shirodaria, Keith Channon

Research output: Contribution to journalComment/debate

Abstract

Although the short- and long-term clinical outcomes of patients with ST-segment elevation myocardial infarction (STEMI) has improved substantially over the last 2 decades the risk of future cardiovascular events, in particular heart failure, remains high [1]. The most important determinant of long-term clinical outcomes after STEMI is infarct size (IS). In a recent meta-analysis, IS measured within 1 month after primary percutaneous intervention (pPCI) was strongly associated with all-cause mortality and hospitalization for heart failure within 1 year [2]. There are currently no established therapies to reduce IS, with the exception of timely reperfusion by pPCI. Furthermore, ischemia-reperfusion injury (IRI) remains a major clinical problem in patients with STEMI...
Original languageEnglish
Pages (from-to)272-274
Number of pages3
JournalInternational Journal of Cardiology
Volume323
DOIs
Publication statusPublished - 15 Jan 2021

Keywords

  • Cardiovascular magnetic resonance imaging
  • Infarct size
  • ST-segment elevation myocardial infarction

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