Timing of rectal cancer surgery following neoadjuvant chemoradiation: How close are we to striking an equipoise?

Savio George Barreto; Bhawna Sirohi; Shailesh V. Shrikhande

doi:10.2217/fon-2016-0478

Timing of rectal cancer surgery following neoadjuvant chemoradiation: How close are we to striking an equipoise?

Savio George Barreto, Bhawna Sirohi, Shailesh V. Shrikhande

College of Medicine and Public Health

Research output: Contribution to journal › Comment/debate

1 Citation (Scopus)

Abstract

The management of locally advanced rectal cancer underwent a paradigm shift from the historical practice of upfront surgery to the use of neoadjuvant chemoradiotherapy followed by surgery after two sentinel observations, namely, the high rates of local recurrence rates after the former and the long-lasting success of the latter in terms of reducing local recurrence rates in randomized controlled trials.

Original language	English
Pages (from-to)	303-305
Number of pages	3
Journal	Future Oncology
Volume	13
Issue number	4
DOIs	https://doi.org/10.2217/fon-2016-0478
Publication status	Published - Feb 2017

Keywords

rectal cancer
Neoadjuvant therapy
surgery
pathology
MRI
survival
meta-analysis
research
randomized controlled trial
outcomes
mortality
fibrosis
morbidity

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title = "Timing of rectal cancer surgery following neoadjuvant chemoradiation: How close are we to striking an equipoise?",

abstract = "The management of locally advanced rectal cancer underwent a paradigm shift from the historical practice of upfront surgery to the use of neoadjuvant chemoradiotherapy followed by surgery after two sentinel observations, namely, the high rates of local recurrence rates after the former and the long-lasting success of the latter in terms of reducing local recurrence rates in randomized controlled trials.",

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AB - The management of locally advanced rectal cancer underwent a paradigm shift from the historical practice of upfront surgery to the use of neoadjuvant chemoradiotherapy followed by surgery after two sentinel observations, namely, the high rates of local recurrence rates after the former and the long-lasting success of the latter in terms of reducing local recurrence rates in randomized controlled trials.

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KW - Neoadjuvant therapy

KW - surgery

KW - pathology

KW - MRI

KW - survival

KW - meta-analysis

KW - research

KW - randomized controlled trial

KW - outcomes

KW - mortality

KW - fibrosis

KW - morbidity

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EP - 305

JO - Future Oncology

JF - Future Oncology

IS - 4

ER -

Timing of rectal cancer surgery following neoadjuvant chemoradiation: How close are we to striking an equipoise?

Abstract

Keywords

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