To improve outcomes of gallbladder cancer we need to better understand it!

Savio Barreto, Amit Dutt

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The famous and most revered Chinese Philosopher, Lao Tzu once said, ‘A journey of a thousand miles begins with a single step’. The words of this wise man hold true for every sphere of life, and certainly medicine is not excluded.

Long-term survival in gallbladder cancer remains poor and there is much to be achieved in terms of improving survival in addition to surgery. However, following the advice of Lao Tzu, the search for an overall improvement in survival of gallbladder cancer requires that we take small, but definite steps forward in our quest to understand this disease in its totality before we consider novel therapies. One such path to achieving this dream has been the concerted efforts of oncologists to delve deeper into the genetic changes that accompany the process of carcinogenesis from normal epithelium. A couple of years ago, while reviewing the published evidence on the genetic landscape in the progression of gallbladder cancer, we developed a carcinogenesis model for tumours evolving by the dysplasia—carcinoma cascade. The reason for choosing the dysplasia—carcinoma cascade was the simple fact that it is the predominant pathway involved in gallbladder carcinogenesis the world over...
Original languageEnglish
Pages (from-to)379-381
Number of pages3
JournalHepatoBiliary Surgery and Nutrition
Issue number4
Publication statusPublished - 1 Aug 2016
Externally publishedYes


  • Gallbladder
  • Carcinogenesis
  • Salmonella
  • Cancer


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