Tools for Cell Signaling: Synthesis of the 3-Phosphatase-Resistant 1,3,4,5-InsP4 Mimic, 1D-myo-Inositol 1,4,5-Trisphosphate 3-Phosphorothioate

Alan P. Kozikowski; Abdul H. Fauq; Robert A. Wilcox; Stefan R. Nahorski

doi:10.1021/jo00088a003

Tools for Cell Signaling: Synthesis of the 3-Phosphatase-Resistant 1,3,4,5-InsP₄ Mimic, 1D-myo-Inositol 1,4,5-Trisphosphate 3-Phosphorothioate

Alan P. Kozikowski, Abdul H. Fauq, Robert A. Wilcox, Stefan R. Nahorski

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The synthesis of 1D-myo-inositol 1,4,5- trisphosphate 3-phosphorothioate, a 3-phosphataseresistant analogue of 1,3,4,5-InsP₄ is reported, and this compound is shown to elicit ⁴⁵Ca²⁺ release with an EC₅₀ which is comparable to that of the natural metabolite, thus supporting the idea that 1,3,4,5-InsP₄ can interact with the 1,4,5-InsP₃ receptors.

Original language	English
Pages (from-to)	2279-2281
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	59
Issue number	9
DOIs	https://doi.org/10.1021/jo00088a003
Publication status	Published - 1 May 1994
Externally published	Yes

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title = "Tools for Cell Signaling: Synthesis of the 3-Phosphatase-Resistant 1,3,4,5-InsP4 Mimic, 1D-myo-Inositol 1,4,5-Trisphosphate 3-Phosphorothioate",

abstract = "The synthesis of 1D-myo-inositol 1,4,5- trisphosphate 3-phosphorothioate, a 3-phosphataseresistant analogue of 1,3,4,5-InsP4 is reported, and this compound is shown to elicit 45Ca2+ release with an EC50 which is comparable to that of the natural metabolite, thus supporting the idea that 1,3,4,5-InsP4 can interact with the 1,4,5-InsP3 receptors.",

author = "Kozikowski, {Alan P.} and Fauq, {Abdul H.} and Wilcox, {Robert A.} and Nahorski, {Stefan R.}",

year = "1994",

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doi = "10.1021/jo00088a003",

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AU - Kozikowski, Alan P.

AU - Fauq, Abdul H.

AU - Wilcox, Robert A.

AU - Nahorski, Stefan R.

PY - 1994/5/1

Y1 - 1994/5/1

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AB - The synthesis of 1D-myo-inositol 1,4,5- trisphosphate 3-phosphorothioate, a 3-phosphataseresistant analogue of 1,3,4,5-InsP4 is reported, and this compound is shown to elicit 45Ca2+ release with an EC50 which is comparable to that of the natural metabolite, thus supporting the idea that 1,3,4,5-InsP4 can interact with the 1,4,5-InsP3 receptors.

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U2 - 10.1021/jo00088a003

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Tools for Cell Signaling: Synthesis of the 3-Phosphatase-Resistant 1,3,4,5-InsP₄ Mimic, 1D-myo-Inositol 1,4,5-Trisphosphate 3-Phosphorothioate

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