TY - JOUR
T1 - Topical interventions to prevent acute radiation dermatitis in head and neck cancer patients
T2 - a systematic review
AU - Ferreira, Elaine Barros
AU - Vasques, Christiane Inocêncio
AU - Gadia, Rafael
AU - Chan, Raymond Javan
AU - Guerra, Eliete Neves Silva
AU - Mezzomo, Luis André
AU - De Luca Canto, Graziela
AU - dos Reis, Paula Elaine Diniz
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Purpose: The purpose of the study is to evaluate the effects of pharmacological and non-pharmacological topical controls in the prevention of radiation dermatitis. Methods: Relevant clinical trials were identified through electronic searching databases CINAHL, CENTRAL, LILACS, PubMed, Scopus, and Web of Science. Handsearching and gray literature searches were also performed to find additional references. Primary outcomes of interest were the development of radiation dermatitis and the time of occurrence of radiation dermatitis. Results: Thirteen randomized clinical trials were included in this review. The trials were published in Chinese, English, or French, from 1980 to 2015. Pharmacological interventions used in the trials were trolamine, aloe vera, allantoin, Lianbai liquid, sucralfate, Na-sucrose octasulfate, olive oil, hialuronic acid, and dexpanthenol. Non-pharmacological topical controls were usual care/institution routine, aqueous cream, mild soap, water thermal gel, placebo, and no intervention. Conclusions: There was no strong evidence that indicates differences between topical pharmacological interventions or non-pharmacological topical controls in the prevention of acute radiation dermatitis among patients with head and neck cancer undergoing radiotherapy.
AB - Purpose: The purpose of the study is to evaluate the effects of pharmacological and non-pharmacological topical controls in the prevention of radiation dermatitis. Methods: Relevant clinical trials were identified through electronic searching databases CINAHL, CENTRAL, LILACS, PubMed, Scopus, and Web of Science. Handsearching and gray literature searches were also performed to find additional references. Primary outcomes of interest were the development of radiation dermatitis and the time of occurrence of radiation dermatitis. Results: Thirteen randomized clinical trials were included in this review. The trials were published in Chinese, English, or French, from 1980 to 2015. Pharmacological interventions used in the trials were trolamine, aloe vera, allantoin, Lianbai liquid, sucralfate, Na-sucrose octasulfate, olive oil, hialuronic acid, and dexpanthenol. Non-pharmacological topical controls were usual care/institution routine, aqueous cream, mild soap, water thermal gel, placebo, and no intervention. Conclusions: There was no strong evidence that indicates differences between topical pharmacological interventions or non-pharmacological topical controls in the prevention of acute radiation dermatitis among patients with head and neck cancer undergoing radiotherapy.
KW - Head and neck cancer
KW - Radiodermatitis
KW - Radiotherapy
KW - Skin care
UR - http://www.scopus.com/inward/record.url?scp=85003828558&partnerID=8YFLogxK
U2 - 10.1007/s00520-016-3521-7
DO - 10.1007/s00520-016-3521-7
M3 - Review article
C2 - 27957620
AN - SCOPUS:85003828558
SN - 0941-4355
VL - 25
SP - 1001
EP - 1011
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
IS - 3
ER -
