TOPICAL THERAPY OF ULCERATIVE HERPETIC KERATITIS WITH HUMAN INTERFERON

Barrie R. Jones, Douglas J. Coster, Michael G. Falcon, K. Cantell

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

55 patients with dendritic ulcer have been treated in a double-blind randomised manner by minimal wiping debridement of their ulcers followed by daily application of either partially purified human interferon (P.I.N.F.) or placebo. There were 6 recurrences of epithelial herpetic disease in 30 patients who received P.I.N.F. and 13 in 25 who received placebo. This provides the long-awaited data proving the antiviral effect of exogenous interferon in treatment of naturally occurring viral disease in man, and furnishes a sighting shot on the lower edge of the target of effective therapy.

Original languageEnglish
Pages (from-to)128
Number of pages1
JournalThe Lancet
Volume308
Issue number7977
DOIs
Publication statusPublished - 17 Jul 1976
Externally publishedYes

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