TOPICAL THERAPY OF ULCERATIVE HERPETIC KERATITIS WITH HUMAN INTERFERON

Barrie R. Jones; Douglas J. Coster; Michael G. Falcon; K. Cantell

doi:10.1016/S0140-6736(76)92850-6

TOPICAL THERAPY OF ULCERATIVE HERPETIC KERATITIS WITH HUMAN INTERFERON

Barrie R. Jones, Douglas J. Coster, Michael G. Falcon, K. Cantell

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

55 patients with dendritic ulcer have been treated in a double-blind randomised manner by minimal wiping debridement of their ulcers followed by daily application of either partially purified human interferon (P.I.N.F.) or placebo. There were 6 recurrences of epithelial herpetic disease in 30 patients who received P.I.N.F. and 13 in 25 who received placebo. This provides the long-awaited data proving the antiviral effect of exogenous interferon in treatment of naturally occurring viral disease in man, and furnishes a sighting shot on the lower edge of the target of effective therapy.

Original language	English
Pages (from-to)	128
Number of pages	1
Journal	The Lancet
Volume	308
Issue number	7977
DOIs	https://doi.org/10.1016/S0140-6736(76)92850-6
Publication status	Published - 17 Jul 1976
Externally published	Yes

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abstract = "55 patients with dendritic ulcer have been treated in a double-blind randomised manner by minimal wiping debridement of their ulcers followed by daily application of either partially purified human interferon (P.I.N.F.) or placebo. There were 6 recurrences of epithelial herpetic disease in 30 patients who received P.I.N.F. and 13 in 25 who received placebo. This provides the long-awaited data proving the antiviral effect of exogenous interferon in treatment of naturally occurring viral disease in man, and furnishes a sighting shot on the lower edge of the target of effective therapy.",

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AU - Cantell, K.

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AB - 55 patients with dendritic ulcer have been treated in a double-blind randomised manner by minimal wiping debridement of their ulcers followed by daily application of either partially purified human interferon (P.I.N.F.) or placebo. There were 6 recurrences of epithelial herpetic disease in 30 patients who received P.I.N.F. and 13 in 25 who received placebo. This provides the long-awaited data proving the antiviral effect of exogenous interferon in treatment of naturally occurring viral disease in man, and furnishes a sighting shot on the lower edge of the target of effective therapy.

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TOPICAL THERAPY OF ULCERATIVE HERPETIC KERATITIS WITH HUMAN INTERFERON

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