Toward benign syntheses of pyridines involving sequential solvent free aldol and Michael addition reactions

Gareth W.V. Cave, Colin L. Raston

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

Krohnke type pyridines are readily accessible via a sequential solventless aldol condensation and Michael addition involving solid NaOH, followed by treatment with ammonium acetate in acetic acid, as a one pot reaction, which enables both symmetrical and unsymmetrical 2,6-bisaryl substituted pyridines to be isolated in high yield, typically >75%.

Original languageEnglish
Pages (from-to)2199-2200
Number of pages2
JournalChemical Communications
Issue number22
DOIs
Publication statusPublished - 21 Nov 2000
Externally publishedYes

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