Towards a unified open access dataset of molecular interactions

Pablo Porras; Elisabet Barrera; Alan Bridge; Noemi del-Toro; Gianni Cesareni; Margaret Duesbury; Henning Hermjakob; Marta Iannuccelli; Igor Jurisica; Max Kotlyar; Luana Licata; Ruth C. Lovering; David J. Lynn; Birgit Meldal; Bindu Nanduri; Kalpana Paneerselvam; Simona Panni; Chiara Pastrello; Matteo Pellegrini; Livia Perfetto; Negin Rahimzadeh; Prashansa Ratan; Sylvie Ricard-Blum; Lukasz Salwinski; Gautam Shirodkar; Anjalia Shrivastava; Sandra Orchard

doi:10.1038/s41467-020-19942-z

Towards a unified open access dataset of molecular interactions

Pablo Porras, Elisabet Barrera, Alan Bridge, Noemi del-Toro, Gianni Cesareni, Margaret Duesbury, Henning Hermjakob, Marta Iannuccelli, Igor Jurisica, Max Kotlyar, Luana Licata, Ruth C. Lovering, David J. Lynn, Birgit Meldal, Bindu Nanduri, Kalpana Paneerselvam, Simona Panni, Chiara Pastrello, Matteo Pellegrini, Livia PerfettoNegin Rahimzadeh, Prashansa Ratan, Sylvie Ricard-Blum, Lukasz Salwinski, Gautam Shirodkar, Anjalia Shrivastava, Sandra Orchard

College of Medicine and Public Health

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Abstract

The International Molecular Exchange (IMEx) Consortium provides scientists with a single body of experimentally verified protein interactions curated in rich contextual detail to an internationally agreed standard. In this update to the work of the IMEx Consortium, we discuss how this initiative has been working in practice, how it has ensured database sustainability, and how it is meeting emerging annotation challenges through the introduction of new interactor types and data formats. Additionally, we provide examples of how IMEx data are being used by biomedical researchers and integrated in other bioinformatic tools and resources.

Original language	English
Article number	6144
Number of pages	12
Journal	Nature Communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-19942-z
Publication status	Published - 1 Dec 2020

Keywords

Biochemical networks
Data publication and archiving
Protein databases
Protein–protein interaction networks
Standardization

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Porras_Towards_P2020Final published version, 1.63 MBLicence: CC BY

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Porras, P., Barrera, E., Bridge, A., del-Toro, N., Cesareni, G., Duesbury, M., Hermjakob, H., Iannuccelli, M., Jurisica, I., Kotlyar, M., Licata, L., Lovering, R. C., Lynn, D. J., Meldal, B., Nanduri, B., Paneerselvam, K., Panni, S., Pastrello, C., Pellegrini, M., ... Orchard, S. (2020). Towards a unified open access dataset of molecular interactions. Nature Communications, 11(1), Article 6144. https://doi.org/10.1038/s41467-020-19942-z

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Porras, P, Barrera, E, Bridge, A, del-Toro, N, Cesareni, G, Duesbury, M, Hermjakob, H, Iannuccelli, M, Jurisica, I, Kotlyar, M, Licata, L, Lovering, RC, Lynn, DJ, Meldal, B, Nanduri, B, Paneerselvam, K, Panni, S, Pastrello, C, Pellegrini, M, Perfetto, L, Rahimzadeh, N, Ratan, P, Ricard-Blum, S, Salwinski, L, Shirodkar, G, Shrivastava, A & Orchard, S 2020, 'Towards a unified open access dataset of molecular interactions', Nature Communications, vol. 11, no. 1, 6144. https://doi.org/10.1038/s41467-020-19942-z

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AU - Barrera, Elisabet

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AU - del-Toro, Noemi

AU - Cesareni, Gianni

AU - Duesbury, Margaret

AU - Hermjakob, Henning

AU - Iannuccelli, Marta

AU - Jurisica, Igor

AU - Kotlyar, Max

AU - Licata, Luana

AU - Lovering, Ruth C.

AU - Lynn, David J.

AU - Meldal, Birgit

AU - Nanduri, Bindu

AU - Paneerselvam, Kalpana

AU - Panni, Simona

AU - Pastrello, Chiara

AU - Pellegrini, Matteo

AU - Perfetto, Livia

AU - Rahimzadeh, Negin

AU - Ratan, Prashansa

AU - Ricard-Blum, Sylvie

AU - Salwinski, Lukasz

AU - Shirodkar, Gautam

AU - Shrivastava, Anjalia

AU - Orchard, Sandra

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Towards a unified open access dataset of molecular interactions

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