Towards a unified open access dataset of molecular interactions

Pablo Porras, Elisabet Barrera, Alan Bridge, Noemi del-Toro, Gianni Cesareni, Margaret Duesbury, Henning Hermjakob, Marta Iannuccelli, Igor Jurisica, Max Kotlyar, Luana Licata, Ruth C. Lovering, David J. Lynn, Birgit Meldal, Bindu Nanduri, Kalpana Paneerselvam, Simona Panni, Chiara Pastrello, Matteo Pellegrini, Livia PerfettoNegin Rahimzadeh, Prashansa Ratan, Sylvie Ricard-Blum, Lukasz Salwinski, Gautam Shirodkar, Anjalia Shrivastava, Sandra Orchard

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The International Molecular Exchange (IMEx) Consortium provides scientists with a single body of experimentally verified protein interactions curated in rich contextual detail to an internationally agreed standard. In this update to the work of the IMEx Consortium, we discuss how this initiative has been working in practice, how it has ensured database sustainability, and how it is meeting emerging annotation challenges through the introduction of new interactor types and data formats. Additionally, we provide examples of how IMEx data are being used by biomedical researchers and integrated in other bioinformatic tools and resources.

Original languageEnglish
Article number6144
Number of pages12
JournalNature Communications
Volume11
Issue number1
DOIs
Publication statusPublished - 1 Dec 2020

Keywords

  • Biochemical networks
  • Data publication and archiving
  • Protein databases
  • Protein–protein interaction networks
  • Standardization

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