Chiral and achiral bipyridines are readily accessible via a solvent-free Michael addition involving solid NaOH, followed by treatment with ammonium acetate in acetic acid, as a 'one pot' more benign protocol, affording pure products in high yield, typically >80%.
|Number of pages||3|
|Publication status||Published - 4 Apr 2005|
- Green chemistry
- Solvent free