Towards benign syntheses of bipyridines: Versatile approach to supramolecular building blocks

Gareth W.V. Cave, Colin L. Raston

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Chiral and achiral bipyridines are readily accessible via a solvent-free Michael addition involving solid NaOH, followed by treatment with ammonium acetate in acetic acid, as a 'one pot' more benign protocol, affording pure products in high yield, typically >80%.

Original languageEnglish
Pages (from-to)2361-2363
Number of pages3
JournalTetrahedron Letters
Volume46
Issue number14
DOIs
Publication statusPublished - 4 Apr 2005
Externally publishedYes

Keywords

  • Green chemistry
  • Ketones
  • Pyridines
  • Solvent free

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