Abstract
Chiral and achiral bipyridines are readily accessible via a solvent-free Michael addition involving solid NaOH, followed by treatment with ammonium acetate in acetic acid, as a 'one pot' more benign protocol, affording pure products in high yield, typically >80%.
Original language | English |
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Pages (from-to) | 2361-2363 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 46 |
Issue number | 14 |
DOIs | |
Publication status | Published - 4 Apr 2005 |
Externally published | Yes |
Keywords
- Green chemistry
- Ketones
- Pyridines
- Solvent free