Transcript Elongation by RNA Polymerase II

Luke A. Selth, Stefan Sigurdsson, Jesper Q. Svejstrup

Research output: Contribution to journalReview articlepeer-review

134 Citations (Scopus)

Abstract

Until recently, it was generally assumed that essentially all regulation of transcription takes place via regions adjacent to the coding region of a gene-namely promoters and enhancers-and that, after recruitment to the promoter, the polymerase simply behaves like a machine, quickly reading the gene. However, over the past decade a revolution in this thinking has occurred, culminating in the idea that transcript elongation is extremely complex and highly regulated and, moreover, that this process significantly affects both the organization and integrity of the genome. This review addresses basic aspects of transcript elongation by RNA polymerase II (RNAPII) and how it relates to other DNA-related processes.

Original languageEnglish
Pages (from-to)271-293
Number of pages23
JournalAnnual Review of Biochemistry
Volume79
DOIs
Publication statusPublished - 7 Jul 2010
Externally publishedYes

Keywords

  • chromatin
  • elongation factors
  • gene traffic
  • transcription-associated recombination
  • transcription-repair coupling

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