Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration: protocol for a systematic review with individual participant data meta-analysis of behavioural interventions for the prevention of early childhood obesity

Kylie E. Hunter, Brittany J. Johnson, Lisa Askie, Rebecca K. Golley, Louise A. Baur, Ian C. Marschner, Rachael W. Taylor, Luke Wolfenden, Charles T. Wood, Seema Mihrshahi, Alison J. Hayes, Chris Rissel, Kristy P. Robledo, Denise A. O'Connor, David Espinoza, Lukas P. Staub, Paul Chadwick, Sarah Taki, Angie Barba, Sol LibesmanMason Aberoumand, Wendy A. Smith, Michelle Sue-See, Kylie D. Hesketh, Jessica L. Thomson, Maria Bryant, Ian M. Paul, Vera Verbestel, Cathleen Odar Stough, Li Ming Wen, Junilla K. Larsen, Sharleen L. O'Reilly, Heather M. Wasser, Jennifer S. Savage, Ken K. Ong, Sarah Jeanne Salvy, Mary Jo Messito, Rachel S. Gross, Levie T. Karssen, Finn E. Rasmussen, Karen Campbell, Ana Maria Linares, Nina Cecilie Øverby, Cristina Palacios, Kaumudi J. Joshipura, Carolina González Acero, Rajalakshmi Lakshman, Amanda L. Thompson, Claudio Maffeis, Emily Oken, Ata Ghaderi, Maribel Campos Rivera, Ana B. Pérez-Expósito, Jinan C. Banna, Kayla De La Haye, Michael Goran, Margrethe Røed, Stephanie Anzman-Frasca, Barry J. Taylor, Anna Lene Seidler, TOPCHILD Collaboration

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Abstract

Introduction Behavioural interventions in early life appear to show some effect in reducing childhood overweight and obesity. However, uncertainty remains regarding their overall effectiveness, and whether effectiveness differs among key subgroups. These evidence gaps have prompted an increase in very early childhood obesity prevention trials worldwide. Combining the individual participant data (IPD) from these trials will enhance statistical power to determine overall effectiveness and enable examination of individual and trial-level subgroups. We present a protocol for a systematic review with IPD meta-analysis to evaluate the effectiveness of obesity prevention interventions commencing antenatally or in the first year after birth, and to explore whether there are differential effects among key subgroups. Methods and analysis Systematic searches of Medline, Embase, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycInfo and trial registries for all ongoing and completed randomised controlled trials evaluating behavioural interventions for the prevention of early childhood obesity have been completed up to March 2021 and will be updated annually to include additional trials. Eligible trialists will be asked to share their IPD; if unavailable, aggregate data will be used where possible. An IPD meta-analysis and a nested prospective meta-analysis will be performed using methodologies recommended by the Cochrane Collaboration. The primary outcome will be body mass index z-score at age 24±6 months using WHO Growth Standards, and effect differences will be explored among prespecified individual and trial-level subgroups. Secondary outcomes include other child weight-related measures, infant feeding, dietary intake, physical activity, sedentary behaviours, sleep, parenting measures and adverse events. Ethics and dissemination Approved by The University of Sydney Human Research Ethics Committee (2020/273) and Flinders University Social and Behavioural Research Ethics Committee (HREC CIA2133-1). Results will be relevant to clinicians, child health services, researchers, policy-makers and families, and will be disseminated via publications, presentations and media releases. PROSPERO registration number CRD42020177408.

Original languageEnglish
Article numbere21048166
Number of pages11
JournalBMJ Open
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 2022

Keywords

  • community child health
  • paediatrics
  • preventive medicine
  • public health

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