Transforming Spirulina maxima Biomass into Ultrathin Bioactive Coatings Using an Atmospheric Plasma Jet: A New Approach to Healing of Infected Wounds

Tuyet Pham, Tien Thanh Nguyen, Ngoc Huu Nguyen, Andrew Hayles, Wenshao Li, Duy Quang Pham, Chung Kim Nguyen, Trung Nguyen, Jitraporn Vongsvivut, Neethu Ninan, Ylias Sabri, Wei Zhang, Krasimir Vasilev, Vi Khanh Truong

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
42 Downloads (Pure)

Abstract

The challenge of wound healing, particularly in patients with comorbidities such as diabetes, is intensified by wound infection and the accelerating problem of bacterial resistance to current remedies such as antibiotics and silver. One promising approach harnesses the bioactive and antibacterial compound C-phycocyanin from the microalga Spirulina maxima. However, the current processes of extracting this compound and developing coatings are unsustainable and difficult to achieve. To circumvent these obstacles, a novel, sustainable argon atmospheric plasma jet (Ar-APJ) technology that transforms S. maxima biomass into bioactive coatings is presented. This Ar-APJ can selectively disrupt the cell walls of S. maxima, converting them into bioactive ultrathin coatings, which are found to be durable under aqueous conditions. The findings demonstrate that Ar-APJ-transformed bioactive coatings show better antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Moreover, these coatings exhibit compatibility with macrophages, induce an anti-inflammatory response by reducing interleukin 6 production, and promote cell migration in keratinocytes. This study offers an innovative, single-step, sustainable technology for transforming microalgae into bioactive coatings. The approach reported here has immense potential for the generation of bioactive coatings for combating wound infections and may offer a significant advance in wound care research and application.

Original languageEnglish
Article number2305469
Number of pages16
JournalSmall
Early online date15 Sept 2023
DOIs
Publication statusE-pub ahead of print - 15 Sept 2023

Keywords

  • antibacterial
  • atmospheric plasma jet
  • bioactive coatings
  • Spirulina maxima
  • wound healing
  • wound infection

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