Abstract
The vortex fluidic device (VFD) is effective in modulating the synthesis of pyrimidine and quinoxaline-based compounds at room temperature and in high yield. The formation of the C–N bond occurs in the absence of a transition-metal catalyst, which avoids the contamination of the products with trace amounts of a transition metal. The systematic investigation of the operating parameters for the microfluidic platform in the confined operation mode established an optimum tilt angle of 45° for a 10 mm diameter borosilicate glass tube rotating at 5000 rpm.
Original language | English |
---|---|
Pages (from-to) | 5957-5963 |
Number of pages | 7 |
Journal | European Journal of Organic Chemistry |
Volume | 2016 |
Issue number | 36 |
DOIs | |
Publication status | Published - Dec 2016 |
Keywords
- Cross-coupling
- Green chemistry
- Nitrogen heterocycles
- Synthetic methods
- Thin films