TY - JOUR
T1 - Transneuronal labelling of neurons in rabbit brain after injection of Herpes simplex virus type 1 into the renal nerve
AU - Ding, Zong Qun
AU - Li, Yu Wen
AU - Wesselingh, S. L.
AU - Blessing, W. W.
PY - 1993/1
Y1 - 1993/1
N2 - We mapped the distribution of virus-labelled neurons in the brain after injection of Herpes simplex virus type 1 (HSV1) into the rabbit renal nerve. Seven days after injection, labelled neurons were observed in four brain regions, the rostral ventrolateral medulla (47 ± 3% of neurons), the A5 area of the lower pons (38 ± 4%), the caudal raphe nuclei and the parapyramidal area of the medulla (13 ± 2%), and the paraventricular nucleus of the hypothalamus (1 ± 1%). In the rostral ventrolateral medulla approximately one half of the HSV1-labelled neurons also contained tyrosine hydroxylase, characterizing them as C1 neurons. In the A5 area virtually all HSV1-labelled neurons also contained tyrosine hydroxylase. In the raphe nuclei and the parapyramidal area 47% of HSV1-positive neurons contained serotonin. The distribution of labelled neurons was similar to that observed after injection of HSV1 into the adrenal gland.
AB - We mapped the distribution of virus-labelled neurons in the brain after injection of Herpes simplex virus type 1 (HSV1) into the rabbit renal nerve. Seven days after injection, labelled neurons were observed in four brain regions, the rostral ventrolateral medulla (47 ± 3% of neurons), the A5 area of the lower pons (38 ± 4%), the caudal raphe nuclei and the parapyramidal area of the medulla (13 ± 2%), and the paraventricular nucleus of the hypothalamus (1 ± 1%). In the rostral ventrolateral medulla approximately one half of the HSV1-labelled neurons also contained tyrosine hydroxylase, characterizing them as C1 neurons. In the A5 area virtually all HSV1-labelled neurons also contained tyrosine hydroxylase. In the raphe nuclei and the parapyramidal area 47% of HSV1-positive neurons contained serotonin. The distribution of labelled neurons was similar to that observed after injection of HSV1 into the adrenal gland.
KW - Catecholamine
KW - Herpes simplex virus
KW - Renal nerve
KW - Rostral ventrolateral medulla
KW - Serotonin
KW - Sympathetic nervous system
UR - http://www.scopus.com/inward/record.url?scp=0027470988&partnerID=8YFLogxK
U2 - 10.1016/0165-1838(93)90338-U
DO - 10.1016/0165-1838(93)90338-U
M3 - Article
C2 - 7679686
AN - SCOPUS:0027470988
VL - 42
SP - 23
EP - 31
JO - Journal of the Autonomic Nervous System
JF - Journal of the Autonomic Nervous System
SN - 0165-1838
IS - 1
ER -