Treatment of Alzheimer's Disease: A Cautionary Note

D. M. Bowen; N. R. Sims; J. S. Benton; G. Curzon; A. N. Davison; D. Neary; D. J. Thomas

doi:10.1056/NEJM198110223051714

Treatment of Alzheimer's Disease: A Cautionary Note

D. M. Bowen, N. R. Sims, J. S. Benton, G. Curzon, A. N. Davison, D. Neary, D. J. Thomas

Research output: Contribution to journal › Letter › peer-review

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Abstract

To the Editor: Now that there is direct evidence of a reduction in acetylcholine synthesis in Alzheimer#x0027; s disease¹^,² as well as a clinical response to an acetylcholine precursor in some patients,³ it can be anticipated that the clinical testing of appropriate agonists will be intensified. However, a word of caution on such studies may be called for. We examined cerebral-biopsy and cerebrospinal-fluid (CSF) samples from seven patients 43 to 66 years old with progressive dementia. Histologic evidence of Alzheimer#x0027; s disease was evident in all but the two youngest patients (men 43 and 50 years old), in whom there was also. . .

Original language	English
Pages (from-to)	1016
Number of pages	1
Journal	New England Journal of Medicine
Volume	305
Issue number	17
DOIs	https://doi.org/10.1056/NEJM198110223051714
Publication status	Published - 22 Oct 1981
Externally published	Yes

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title = "Treatment of Alzheimer's Disease: A Cautionary Note",

abstract = "To the Editor: Now that there is direct evidence of a reduction in acetylcholine synthesis in Alzheimer#x0027; s disease1,2 as well as a clinical response to an acetylcholine precursor in some patients,3 it can be anticipated that the clinical testing of appropriate agonists will be intensified. However, a word of caution on such studies may be called for. We examined cerebral-biopsy and cerebrospinal-fluid (CSF) samples from seven patients 43 to 66 years old with progressive dementia. Histologic evidence of Alzheimer#x0027; s disease was evident in all but the two youngest patients (men 43 and 50 years old), in whom there was also. . .",

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T2 - A Cautionary Note

AU - Bowen, D. M.

AU - Sims, N. R.

AU - Benton, J. S.

AU - Curzon, G.

AU - Davison, A. N.

AU - Neary, D.

AU - Thomas, D. J.

PY - 1981/10/22

Y1 - 1981/10/22

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AB - To the Editor: Now that there is direct evidence of a reduction in acetylcholine synthesis in Alzheimer#x0027; s disease1,2 as well as a clinical response to an acetylcholine precursor in some patients,3 it can be anticipated that the clinical testing of appropriate agonists will be intensified. However, a word of caution on such studies may be called for. We examined cerebral-biopsy and cerebrospinal-fluid (CSF) samples from seven patients 43 to 66 years old with progressive dementia. Histologic evidence of Alzheimer#x0027; s disease was evident in all but the two youngest patients (men 43 and 50 years old), in whom there was also. . .

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JF - New England Journal of Medicine

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Treatment of Alzheimer's Disease: A Cautionary Note

Abstract

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