Treatment of Alzheimer's Disease: A Cautionary Note

D. M. Bowen; N. R. Sims; J. S. Benton; G. Curzon; A. N. Davison; D. Neary; D. J. Thomas

doi:10.1056/NEJM198110223051714

Treatment of Alzheimer's Disease: A Cautionary Note

D. M. Bowen
, N. R. Sims
, J. S. Benton
, G. Curzon
, A. N. Davison
, D. Neary
, D. J. Thomas

Research output: Contribution to journal › Letter › peer-review

29 Citations (Scopus)

Abstract

To the Editor: Now that there is direct evidence of a reduction in acetylcholine synthesis in Alzheimer#x0027; s disease¹^,² as well as a clinical response to an acetylcholine precursor in some patients,³ it can be anticipated that the clinical testing of appropriate agonists will be intensified. However, a word of caution on such studies may be called for. We examined cerebral-biopsy and cerebrospinal-fluid (CSF) samples from seven patients 43 to 66 years old with progressive dementia. Histologic evidence of Alzheimer#x0027; s disease was evident in all but the two youngest patients (men 43 and 50 years old), in whom there was also. . .

Original language	English
Pages (from-to)	1016
Number of pages	1
Journal	New England Journal of Medicine
Volume	305
Issue number	17
DOIs	https://doi.org/10.1056/NEJM198110223051714
Publication status	Published - 22 Oct 1981
Externally published	Yes

Access to Document

10.1056/NEJM198110223051714Licence: In Copyright

Cite this

@article{70ea8dc45f5a4d63acdf966bda2c479e,

title = "Treatment of Alzheimer's Disease: A Cautionary Note",

abstract = "To the Editor: Now that there is direct evidence of a reduction in acetylcholine synthesis in Alzheimer\#x0027; s disease1,2 as well as a clinical response to an acetylcholine precursor in some patients,3 it can be anticipated that the clinical testing of appropriate agonists will be intensified. However, a word of caution on such studies may be called for. We examined cerebral-biopsy and cerebrospinal-fluid (CSF) samples from seven patients 43 to 66 years old with progressive dementia. Histologic evidence of Alzheimer\#x0027; s disease was evident in all but the two youngest patients (men 43 and 50 years old), in whom there was also. . .",

author = "Bowen, \{D. M.\} and Sims, \{N. R.\} and Benton, \{J. S.\} and G. Curzon and Davison, \{A. N.\} and D. Neary and Thomas, \{D. J.\}",

year = "1981",

month = oct,

day = "22",

doi = "10.1056/NEJM198110223051714",

language = "English",

volume = "305",

pages = "1016",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachussetts Medical Society",

number = "17",

}

TY - JOUR

T1 - Treatment of Alzheimer's Disease

T2 - A Cautionary Note

AU - Bowen, D. M.

AU - Sims, N. R.

AU - Benton, J. S.

AU - Curzon, G.

AU - Davison, A. N.

AU - Neary, D.

AU - Thomas, D. J.

PY - 1981/10/22

Y1 - 1981/10/22

N2 - To the Editor: Now that there is direct evidence of a reduction in acetylcholine synthesis in Alzheimer#x0027; s disease1,2 as well as a clinical response to an acetylcholine precursor in some patients,3 it can be anticipated that the clinical testing of appropriate agonists will be intensified. However, a word of caution on such studies may be called for. We examined cerebral-biopsy and cerebrospinal-fluid (CSF) samples from seven patients 43 to 66 years old with progressive dementia. Histologic evidence of Alzheimer#x0027; s disease was evident in all but the two youngest patients (men 43 and 50 years old), in whom there was also. . .

AB - To the Editor: Now that there is direct evidence of a reduction in acetylcholine synthesis in Alzheimer#x0027; s disease1,2 as well as a clinical response to an acetylcholine precursor in some patients,3 it can be anticipated that the clinical testing of appropriate agonists will be intensified. However, a word of caution on such studies may be called for. We examined cerebral-biopsy and cerebrospinal-fluid (CSF) samples from seven patients 43 to 66 years old with progressive dementia. Histologic evidence of Alzheimer#x0027; s disease was evident in all but the two youngest patients (men 43 and 50 years old), in whom there was also. . .

UR - https://www.scopus.com/pages/publications/0019863017

U2 - 10.1056/NEJM198110223051714

DO - 10.1056/NEJM198110223051714

M3 - Letter

C2 - 7278915

AN - SCOPUS:0019863017

SN - 0028-4793

VL - 305

SP - 1016

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 17

ER -

Treatment of Alzheimer's Disease: A Cautionary Note

Abstract

Access to Document

Other files and links

Fingerprint

Cite this