Treatment of chronic myeloid leukemia: assessing risk, monitoring response, and optimizing outcome

Naranie Shanmuganathan, Devendra Keshaorao Hiwase, David Morrall Ross

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Over the past two decades, tyrosine kinase inhibitors have become the foundation of chronic myeloid leukemia (CML) treatment. The choice between imatinib and newer tyrosine kinase inhibitors (TKIs) needs to be balanced against the known toxicity and efficacy data for each drug, the therapeutic goal being to maximize molecular response assessed by BCR-ABL RQ-PCR assay. There is accumulating evidence that the early achievement of molecular targets is a strong predictor of superior long-term outcomes. Early response assessment provides the opportunity to intervene early with the aim of ensuring an optimal response. Failure to achieve milestones or loss of response can have diverse causes. We describe how clinical and laboratory monitoring can be used to ensure that each patient is achieving an optimal response and, in patients who do not reach optimal response milestones, how the monitoring results can be used to detect resistance and understand its origins.

Original languageEnglish
Pages (from-to)2799-2810
Number of pages12
JournalLeukemia and Lymphoma
Volume58
Issue number12
DOIs
Publication statusPublished - 2017

Keywords

  • BCR-ABL
  • Chronic myeloid leukemia
  • minimal residual disease
  • resistance

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