TY - JOUR
T1 - Treatment of eating disorders
T2 - A systematic meta-review of meta-analyses and network meta-analyses
AU - Monteleone, Alessio Maria
AU - Pellegrino, Francesca
AU - Croatto, Giovanni
AU - Carfagno, Marco
AU - Hilbert, Anja
AU - Treasure, Janet
AU - Wade, Tracey
AU - Bulik, Cynthia M.
AU - Zipfel, Stephan
AU - Hay, Phillipa
AU - Schmidt, Ulrike
AU - Castellini, Giovanni
AU - Favaro, Angela
AU - Fernandez-Aranda, Fernando
AU - Il Shin, Jae
AU - Voderholzer, Ulrich
AU - Ricca, Valdo
AU - Moretti, Davide
AU - Busatta, Daniele
AU - Abbate-Daga, Giovanni
AU - Ciullini, Filippo
AU - Cascino, Giammarco
AU - Monaco, Francesco
AU - Correll, Christoph U.
AU - Solmi, Marco
PY - 2022/11
Y1 - 2022/11
N2 - MONTELEONE, A.M., F. Pellegrino, G. Croatto, M. Carfagno, A. Hilbert, J. Treasure, T. Wade, C. Bulik, S. Zipfel, P. Hay, U. Schmidt, G. Castellini, A. Favaro, F. Fernandez-Aranda, J. Il Shin, U. Voderholzer, V. Ricca, D. Moretti, D. Busatta, G. Abbate-Daga, F. Ciullini, G. Cascino, F. Monaco, C.U. Correll and M. Solmi. Treatment of Eating Disorders: a systematic meta-review of meta-analyses and network meta-analyses. NEUROSCI BIOBEHAV REV 21(1) XXX-XXX, 2022.- Treatment efficacy for eating disorders (EDs) is modest and guidelines differ. We summarized findings/quality of (network) meta-analyses (N)MA of randomized controlled trials (RCTs) in EDs. Systematic meta-review ((N)MA of RCTs, ED, active/inactive control), using (anorexia or bulimia or eating disorder) AND (meta-analy*) in PubMed/PsycINFO/Cochrane database up to December 15th, 2020. Standardized mean difference, odds/risk ratio vs control were summarized at end of treatment and follow-up. Interventions involving family (family-based therapy, FBT) outperformed active control in adults/adolescents with anorexia nervosa (AN), and in adolescents with bulimia nervosa (BN). In adults with BN, individual cognitive behavioural therapy (CBT)-ED had the broadest efficacy versus active control; also, antidepressants outperformed active. In mixed age groups with binge-eating disorder (BED), psychotherapy, and lisdexamfetamine outperformed active control. Antidepressants, stimulants outperformed placebo, despite lower acceptability, as did CBT-ED versus waitlist/no treatment. Family-based therapy is effective in AN and BN (adolescents). CBT-ED has the largest efficacy in BN (adults), followed by antidepressants, as well as psychotherapy in BED (mixed). Medications have short-term efficacy in BED (adults).
AB - MONTELEONE, A.M., F. Pellegrino, G. Croatto, M. Carfagno, A. Hilbert, J. Treasure, T. Wade, C. Bulik, S. Zipfel, P. Hay, U. Schmidt, G. Castellini, A. Favaro, F. Fernandez-Aranda, J. Il Shin, U. Voderholzer, V. Ricca, D. Moretti, D. Busatta, G. Abbate-Daga, F. Ciullini, G. Cascino, F. Monaco, C.U. Correll and M. Solmi. Treatment of Eating Disorders: a systematic meta-review of meta-analyses and network meta-analyses. NEUROSCI BIOBEHAV REV 21(1) XXX-XXX, 2022.- Treatment efficacy for eating disorders (EDs) is modest and guidelines differ. We summarized findings/quality of (network) meta-analyses (N)MA of randomized controlled trials (RCTs) in EDs. Systematic meta-review ((N)MA of RCTs, ED, active/inactive control), using (anorexia or bulimia or eating disorder) AND (meta-analy*) in PubMed/PsycINFO/Cochrane database up to December 15th, 2020. Standardized mean difference, odds/risk ratio vs control were summarized at end of treatment and follow-up. Interventions involving family (family-based therapy, FBT) outperformed active control in adults/adolescents with anorexia nervosa (AN), and in adolescents with bulimia nervosa (BN). In adults with BN, individual cognitive behavioural therapy (CBT)-ED had the broadest efficacy versus active control; also, antidepressants outperformed active. In mixed age groups with binge-eating disorder (BED), psychotherapy, and lisdexamfetamine outperformed active control. Antidepressants, stimulants outperformed placebo, despite lower acceptability, as did CBT-ED versus waitlist/no treatment. Family-based therapy is effective in AN and BN (adolescents). CBT-ED has the largest efficacy in BN (adults), followed by antidepressants, as well as psychotherapy in BED (mixed). Medications have short-term efficacy in BED (adults).
KW - Eating disorders
KW - Psychopharmacology
KW - Psychotherapy
KW - Randomized controlled trials
KW - Treatment
KW - Umbrella review
UR - http://www.scopus.com/inward/record.url?scp=85138092267&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2022.104857
DO - 10.1016/j.neubiorev.2022.104857
M3 - Review article
C2 - 36084848
AN - SCOPUS:85138092267
SN - 0149-7634
VL - 142
JO - NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
JF - NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
M1 - 104857
ER -