Treatment of reflux oesophagitis with a carbenoxolone/ antacid/alginate preparation: A double-blind controlled trial

G. P. Young, G. S. Nagy, J. Myren, I. J. Kronborg, K. R. Logan, P. I. Reed, J. L. Hopper

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Twenty-nine patients were treated with a carbenoxolone/antacid/alginate preparation (Pyrogastrone® and 30 with antacid/alginate alone four times each day for 8 weeks, in a double-blind study, to ascertain the value of carbenoxolone in the treatment of patients with endoscopically confirmed reflux oesophagitis. Symptom review every 2 weeks and endoscopic findings every 4 weeks were converted to a 6-point grading system to facilitate statistical comparison, using a stochastic model for predicting the rate of change in grades during treatment. Carbenoxolone-treated patients showed an 82% improvement in symptom grades over 8 weeks and improved 50% faster (P< 0.01) than did control patients, who showed a 63% improvement. Endoscopic improvement was not significantly different in the first 4 weeks, although healing was better maintained in carbenoxolone-treated patients during the second 4 weeks (P < 0.05). At the low doses used (5 × 20mg daily) no significant side effects of carbenoxolone were encountered. Pyrogastrone should be considered as a therapeutic alternative in patients who fail to respond to routine management with antacids.

Original languageEnglish
Pages (from-to)1098-1104
Number of pages7
JournalScandinavian Journal of Gastroenterology
Volume21
Issue number9
DOIs
Publication statusPublished - Sep 1986
Externally publishedYes

Keywords

  • Alginate
  • Antacids
  • Carbenoxolone
  • Dyspepsia
  • Endoscopy
  • Gastro-oeso-phageal reflux
  • Oesophagitis
  • Side effects

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