Trefoil Factor Family: Unresolved Questions and Clinical Perspectives

Nayara Braga Emídio; Werner Hoffmann; Stuart M. Brierley; Markus Muttenthaler

doi:10.1016/j.tibs.2019.01.004

Trefoil Factor Family: Unresolved Questions and Clinical Perspectives

Nayara Braga Emídio, Werner Hoffmann, Stuart M. Brierley, Markus Muttenthaler

College of Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The trefoil factor family of peptides (TFF1, TFF2, TFF3) with their lectin activities play important roles in mucosal protection and repair. However, major gaps in understanding their molecular function have hampered therapeutic development for gastrointestinal disorders. We provide here a critical overview of the status quo.

Original language	English
Pages (from-to)	387-390
Number of pages	4
Journal	Trends in Biochemical Sciences
Volume	44
Issue number	5
DOIs	https://doi.org/10.1016/j.tibs.2019.01.004
Publication status	Published - 2019

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title = "Trefoil Factor Family: Unresolved Questions and Clinical Perspectives",

abstract = "The trefoil factor family of peptides (TFF1, TFF2, TFF3) with their lectin activities play important roles in mucosal protection and repair. However, major gaps in understanding their molecular function have hampered therapeutic development for gastrointestinal disorders. We provide here a critical overview of the status quo.",

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AB - The trefoil factor family of peptides (TFF1, TFF2, TFF3) with their lectin activities play important roles in mucosal protection and repair. However, major gaps in understanding their molecular function have hampered therapeutic development for gastrointestinal disorders. We provide here a critical overview of the status quo.

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