Trefoil Factor Family: Unresolved Questions and Clinical Perspectives

Nayara Braga Emídio, Werner Hoffmann, Stuart M. Brierley, Markus Muttenthaler

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


The trefoil factor family of peptides (TFF1, TFF2, TFF3) with their lectin activities play important roles in mucosal protection and repair. However, major gaps in understanding their molecular function have hampered therapeutic development for gastrointestinal disorders. We provide here a critical overview of the status quo.

Original languageEnglish
Pages (from-to)387-390
Number of pages4
JournalTrends in Biochemical Sciences
Issue number5
Publication statusPublished - May 2019


  • cell migration
  • gastrointestinal wound healing
  • lectin
  • mucins
  • mucosal protection
  • mucositis


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