Trefoil Factor Family: Unresolved Questions and Clinical Perspectives

Nayara Braga Emídio; Werner Hoffmann; Stuart M. Brierley; Markus Muttenthaler

doi:10.1016/j.tibs.2019.01.004

Trefoil Factor Family: Unresolved Questions and Clinical Perspectives

Nayara Braga Emídio, Werner Hoffmann, Stuart M. Brierley, Markus Muttenthaler

College of Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

The trefoil factor family of peptides (TFF1, TFF2, TFF3) with their lectin activities play important roles in mucosal protection and repair. However, major gaps in understanding their molecular function have hampered therapeutic development for gastrointestinal disorders. We provide here a critical overview of the status quo.

Original language	English
Pages (from-to)	387-390
Number of pages	4
Journal	Trends in Biochemical Sciences
Volume	44
Issue number	5
DOIs	https://doi.org/10.1016/j.tibs.2019.01.004
Publication status	Published - May 2019

Keywords

cell migration
gastrointestinal wound healing
lectin
mucins
mucosal protection
mucositis

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10.1016/j.tibs.2019.01.004

Cite this

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title = "Trefoil Factor Family: Unresolved Questions and Clinical Perspectives",

abstract = "The trefoil factor family of peptides (TFF1, TFF2, TFF3) with their lectin activities play important roles in mucosal protection and repair. However, major gaps in understanding their molecular function have hampered therapeutic development for gastrointestinal disorders. We provide here a critical overview of the status quo.",

keywords = "cell migration, gastrointestinal wound healing, lectin, mucins, mucosal protection, mucositis",

author = "{Braga Em{\'i}dio}, Nayara and Werner Hoffmann and Brierley, {Stuart M.} and Markus Muttenthaler",

year = "2019",

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AU - Hoffmann, Werner

AU - Brierley, Stuart M.

AU - Muttenthaler, Markus

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AB - The trefoil factor family of peptides (TFF1, TFF2, TFF3) with their lectin activities play important roles in mucosal protection and repair. However, major gaps in understanding their molecular function have hampered therapeutic development for gastrointestinal disorders. We provide here a critical overview of the status quo.

KW - cell migration

KW - gastrointestinal wound healing

KW - lectin

KW - mucins

KW - mucosal protection

KW - mucositis

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DO - 10.1016/j.tibs.2019.01.004

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JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

SN - 0968-0004

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ER -

Trefoil Factor Family: Unresolved Questions and Clinical Perspectives

Abstract

Keywords

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