TY - JOUR
T1 - Trends of national and sub-national burden attributed to kidney dysfunction risk factor in Iran
T2 - 1990-2019
AU - Nejadghaderi, Seyed Aria
AU - Moghaddam, Sahar Saeedi
AU - Keykhaei, Mohammad
AU - Shobeiri, Parnian
AU - Rezaei, Negar
AU - Rezaei, Nazila
AU - GBD 2019 Iran Kidney Dysfunction Collaborators
AU - Naghavi, Mohsen
AU - Larijani, Bagher
AU - Farzadfar, Farshad
AU - Abdollahi, Ashkan
AU - Ahmadi, Ali
AU - Ahmadi, Sepideh
AU - Alatab, Sudabeh
AU - Arabloo, Jalal
AU - Arjomandzadegan, Mohammad
AU - Athari, Seyyed Shamsadin
AU - Azadnajafabad, Sina
AU - Azangou-Khyavy, Mohammadreza
AU - Baghcheghi, Nayereh
AU - Bagherieh, Sara
AU - Barati, Shirin
AU - Dehghan, Azizallah
AU - Fatehizadeh, Ali
AU - Ghadirian, Fataneh
AU - Gholamalizadeh, Maryam
AU - Gholami, Ali
AU - Gohari, Kimiya
AU - Hassankhani, Hadi
AU - Jokar, Mohammad
AU - Khorashadizadeh, Fatemeh
AU - Kompani, Farzad
AU - Koohestani, Hamid Reza
AU - Mahjoub, Soleiman
AU - Mahmoodpoor, Ata
AU - Rad, Elaheh Malakan
AU - Mobayen, Mohammadreza
AU - Mohammadi, Esmaeil
AU - Moradi, Yousef
AU - Morovatdar, Negar
AU - Noori, Maryam
AU - Okati-Aliabad, Hassan
AU - Pourali, Ghazaleh
AU - Rafferty, Quinn
AU - Rashedi, Sina
AU - Rashidi, Mahsa
AU - Rashidi, Mohammad-Mahdi
AU - Sahebkar, Amirhossein
AU - Shorofi, Seyed Afshin
AU - Tabatabaei, Seyyed Mohammad
AU - Taheri, Majid
AU - Taherkhani, Amir
AU - Zahir, Mazyar
AU - Zangiabadian, Moein
AU - Zare, Iman
PY - 2023
Y1 - 2023
N2 - Background: Kidney dysfunction is a risk factor for cardiovascular disease and chronic kidney disease. Herein, we aimed to describe the attributable burden of kidney dysfunction at the national and sub-national levels in Iran. Methods: The Global Burden of Disease (GBD) 2019 data were extracted on the deaths, disability-adjusted life years (DALYs), years of life lost, and years lived with disability attributed to the risk factor of kidney dysfunction by age and sex at the national and provincial levels from 1990-2019. Also, risk exposure was reported by summary exposure value (SEV) with a range of 0 to 100. The estimated values were based on a comparative risk assessment framework. Results: In 2019, the age-standardized death rate and age-standardized DALYs rate attributable to kidney dysfunction were 58.2 (95% uncertainty interval of 48.8-68.1) and 1127.2 (981.1-1282.7) per 100,000 population in Iran, respectively. Also, the Sistan and Baluchistan province (1729.3 [1478.3-2006.4]) and the province of Tehran (681.9 [571.4-809.8]) had the greatest and lowest age-standardized DALYs rates, respectively. Nationally, SEVs increased from 22.8 to 26.2. The age-standardized burden attributable to kidney dysfunction had a positive association with age advancement. The attributable age-standardized deaths and DALYs rates in all socio-demographic index regions decreased from 1990-2019. Also, the highest and lowest attributable age-standardized DALYs rates of kidney dysfunction came from ischemic heart disease and peripheral artery disease in 2019, respectively. Conclusion: Although the attributed age-standardized DALYs and death rates decreased from 1990-2019, risk exposure increased and remains a crucial risk factor in Iran. Therefore, policymakers should consider preparing a preventive program that takes into account different levels of prevention of kidney dysfunction.
AB - Background: Kidney dysfunction is a risk factor for cardiovascular disease and chronic kidney disease. Herein, we aimed to describe the attributable burden of kidney dysfunction at the national and sub-national levels in Iran. Methods: The Global Burden of Disease (GBD) 2019 data were extracted on the deaths, disability-adjusted life years (DALYs), years of life lost, and years lived with disability attributed to the risk factor of kidney dysfunction by age and sex at the national and provincial levels from 1990-2019. Also, risk exposure was reported by summary exposure value (SEV) with a range of 0 to 100. The estimated values were based on a comparative risk assessment framework. Results: In 2019, the age-standardized death rate and age-standardized DALYs rate attributable to kidney dysfunction were 58.2 (95% uncertainty interval of 48.8-68.1) and 1127.2 (981.1-1282.7) per 100,000 population in Iran, respectively. Also, the Sistan and Baluchistan province (1729.3 [1478.3-2006.4]) and the province of Tehran (681.9 [571.4-809.8]) had the greatest and lowest age-standardized DALYs rates, respectively. Nationally, SEVs increased from 22.8 to 26.2. The age-standardized burden attributable to kidney dysfunction had a positive association with age advancement. The attributable age-standardized deaths and DALYs rates in all socio-demographic index regions decreased from 1990-2019. Also, the highest and lowest attributable age-standardized DALYs rates of kidney dysfunction came from ischemic heart disease and peripheral artery disease in 2019, respectively. Conclusion: Although the attributed age-standardized DALYs and death rates decreased from 1990-2019, risk exposure increased and remains a crucial risk factor in Iran. Therefore, policymakers should consider preparing a preventive program that takes into account different levels of prevention of kidney dysfunction.
KW - chronic kidney disease
KW - DALYs
KW - Global Burden of Disease
KW - Iran
KW - kidney dysfunction
KW - mortality risk factor
UR - http://www.scopus.com/inward/record.url?scp=85150053046&partnerID=8YFLogxK
U2 - 10.3389/fendo.2023.1115833
DO - 10.3389/fendo.2023.1115833
M3 - Article
AN - SCOPUS:85150053046
SN - 1664-2392
VL - 14
SP - 1
EP - 12
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
M1 - 1115833
ER -
