Trough concentrations of vancomycin: adult therapeutic targets are not appropriate for children

Claire Gordon, Chantelle Thompson, Jonathon Carapetis, John Turnidge, Charles Kilburn, Bart Currie

    Research output: Contribution to journalReview articlepeer-review

    39 Citations (Scopus)


    Despite the need for effective vancomycin therapy, there are few data guiding vancomycin monitoring in children. We reviewed retrospectively vancomycin use in children 1 month to 12 years of age. Initial and adjusted target trough vancomycin concentrations in serum were infrequently achieved regardless of the dosing schedule. Currently recommended trough concentrations need to be re-examined with a more detailed pharmacokinetic study in children.

    Original languageEnglish
    Pages (from-to)1269-1271
    Number of pages3
    JournalPediatric Infectious Disease Journal
    Issue number12
    Publication statusPublished - Dec 2012


    • Staphylococcus aureus
    • Therapeutic drug monitoring
    • Vancomycin

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