Trough concentrations of vancomycin: adult therapeutic targets are not appropriate for children

Claire Gordon; Chantelle Thompson; Jonathon Carapetis; John Turnidge; Charles Kilburn; Bart Currie

doi:10.1097/INF.0b013e31826a3eaf

Trough concentrations of vancomycin: adult therapeutic targets are not appropriate for children

Claire Gordon, Chantelle Thompson, Jonathon Carapetis, John Turnidge, Charles Kilburn, Bart Currie

Research output: Contribution to journal › Review article › peer-review

39 Citations (Scopus)

Abstract

Despite the need for effective vancomycin therapy, there are few data guiding vancomycin monitoring in children. We reviewed retrospectively vancomycin use in children 1 month to 12 years of age. Initial and adjusted target trough vancomycin concentrations in serum were infrequently achieved regardless of the dosing schedule. Currently recommended trough concentrations need to be re-examined with a more detailed pharmacokinetic study in children.

Original language	English
Pages (from-to)	1269-1271
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	31
Issue number	12
DOIs	https://doi.org/10.1097/INF.0b013e31826a3eaf
Publication status	Published - Dec 2012

Keywords

Staphylococcus aureus
Therapeutic drug monitoring
Vancomycin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1097/INF.0b013e31826a3eaf

Cite this

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abstract = "Despite the need for effective vancomycin therapy, there are few data guiding vancomycin monitoring in children. We reviewed retrospectively vancomycin use in children 1 month to 12 years of age. Initial and adjusted target trough vancomycin concentrations in serum were infrequently achieved regardless of the dosing schedule. Currently recommended trough concentrations need to be re-examined with a more detailed pharmacokinetic study in children.",

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AU - Gordon, Claire

AU - Thompson, Chantelle

AU - Carapetis, Jonathon

AU - Turnidge, John

AU - Kilburn, Charles

AU - Currie, Bart

PY - 2012/12

Y1 - 2012/12

N2 - Despite the need for effective vancomycin therapy, there are few data guiding vancomycin monitoring in children. We reviewed retrospectively vancomycin use in children 1 month to 12 years of age. Initial and adjusted target trough vancomycin concentrations in serum were infrequently achieved regardless of the dosing schedule. Currently recommended trough concentrations need to be re-examined with a more detailed pharmacokinetic study in children.

AB - Despite the need for effective vancomycin therapy, there are few data guiding vancomycin monitoring in children. We reviewed retrospectively vancomycin use in children 1 month to 12 years of age. Initial and adjusted target trough vancomycin concentrations in serum were infrequently achieved regardless of the dosing schedule. Currently recommended trough concentrations need to be re-examined with a more detailed pharmacokinetic study in children.

KW - Staphylococcus aureus

KW - Therapeutic drug monitoring

KW - Vancomycin

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DO - 10.1097/INF.0b013e31826a3eaf

M3 - Review article

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VL - 31

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ER -

Trough concentrations of vancomycin: adult therapeutic targets are not appropriate for children

Abstract

Keywords

UN SDGs

Access to Document

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