TRPA1 detects environmental chemicals and induces avoidance behavior and arousal from sleep

Toru Yonemitsu, Chiharu Kuroki, Nobuaki Takahashi, Yasuo Mori, Yuichi Kanmura, Hideki Kashiwadani, Youichirou Ootsuka, Tomoyuki Kuwaki

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)

    Abstract

    Detecting threats and escaping before serious confrontations are important for animals to avoid danger and death. Transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily, is expressed in a subset of sensory neurons and mediates nociception evoked by pungent chemicals. Using behavioral testing, we found that TRPA1 knockout mice failed to avoid entering a chamber filled with vapor of formalin, allyl isothiocyanate, and acrolein. The avoidance behavior was blocked by nasal but not subcutaneous administration of a blocker to TRPA1. We also found that TRPA1 knockout mice did not wake when exposed to formalin during sleep. Additionally, the spinal trigeminal nucleus, the first relay neurons of the trigeminal system, showed massive expression of c-Fos after a brief (3â€...min) exposure to formalin vapor. TRPA1 seems to be a sentinel for environmental chemicals and induces avoidance behaviors and waking by way of the trigeminal system.

    Original languageEnglish
    Article number3100
    Pages (from-to)3100
    Number of pages5
    JournalScientific Reports
    Volume3
    DOIs
    Publication statusPublished - 31 Oct 2013

    Fingerprint Dive into the research topics of 'TRPA1 detects environmental chemicals and induces avoidance behavior and arousal from sleep'. Together they form a unique fingerprint.

    Cite this