Tween 80 and its derivative oleic acid promote the growth of Corynebacterium accolens and inhibit Staphylococcus aureus clinical isolates

In health, the human nasal cavity is colonized by a wide variety of commensal bacteria and pathobionts and is dominated by Actinobacteria (mainly Corynebacteriaceae)and Firmicutes (mainly Staphylococcaceae). In the context of chronic rhinosinusitis (CRS), however, an imbalance or dysbiosis occurs that is characterized by a decreased relative abundance of Actinobacteria and an overgrowth of pathogens such as Staphylococcus aureus. The fatty acid Tween 80 is commonly used as an excipientin nasal formulations to promote the solubilization of the active drug and is approved by the U.S. Food and Drug Ad-ministration (FDA) at a maximum concentration of 0.5%.