TY - JOUR
T1 - UGT3A: novel UDP-glycosyltransferases of the UGT superfamily
AU - Meech, Robyn
AU - Mackenzie, Peter
PY - 2010/2
Y1 - 2010/2
N2 - Mammalian UDP-glycosyltransferases (UGTs) are divided into four families: UGT1, UGT2, UGT3, and UGT8. UGT3 is the last of the gene families to be identified, and until relatively recently, little was known about the function of these enzymes. In this article, we present new analyses of the UGT3 family genes, including the structure of the UGT3A locus, interspecies sequence conservation, single nucleotide polymorphisms, and splice variants. We also review recently published work that has revealed that one member of this family, UGT3A1, has a unique enzymatic function: N-acetylglucosaminidation. Finally, we discuss the possible biological significance of the UGT3A enzymes.
AB - Mammalian UDP-glycosyltransferases (UGTs) are divided into four families: UGT1, UGT2, UGT3, and UGT8. UGT3 is the last of the gene families to be identified, and until relatively recently, little was known about the function of these enzymes. In this article, we present new analyses of the UGT3 family genes, including the structure of the UGT3A locus, interspecies sequence conservation, single nucleotide polymorphisms, and splice variants. We also review recently published work that has revealed that one member of this family, UGT3A1, has a unique enzymatic function: N-acetylglucosaminidation. Finally, we discuss the possible biological significance of the UGT3A enzymes.
KW - Gene conservation
KW - Gene duplication
KW - Gene expression
KW - N-acetylglucosaminides
KW - SNPs
KW - UDP-glycosyltransferases
KW - UDP-N-acetylglucosamine
KW - Ursodeoxycholicacid
UR - http://informahealthcare.com.ezproxy.flinders.edu.au/doi/pdf/10.3109/03602530903205823?cookieSet=1
UR - http://www.scopus.com/inward/record.url?scp=74549142010&partnerID=8YFLogxK
U2 - 10.3109/03602530903205823
DO - 10.3109/03602530903205823
M3 - Review article
VL - 42
SP - 45
EP - 54
JO - Drug Metabolism Reviews
JF - Drug Metabolism Reviews
SN - 0360-2532
IS - 1
ER -