Ultra-small gold nanoclusters assembled on plasma polymer-modified zeolites: a multifunctional nanohybrid with anti-haemorrhagic and anti-inflammatory properties

Laura E. González García, Neethu Ninan, Johanna Simon, Rahul Madathiparambil Visalakshan, Richard Bright, Satriyo K. Wahono, Kostya Ostrikov, Volker Mailänder, Katharina Landfester, Nirmal Goswami, Krasimir Vasilev

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Hemostatic agents are pivotal for managing clinical and traumatic bleeding during emergency and domestic circumstances. Herein, a novel functional hybrid nanocomposite material consisting of plasma polymer-modified zeolite 13X and ultra-small gold nanoclusters (AuNCs) was fabricated as an efficient hemostatic agent. The surface of zeolite 13X was functionalised with amine groups which served as binding sites for carboxylate terminated AuNCs. Protein corona studies revealed the enhanced adsorption of two proteins, namely, coagulation factors and plasminogen as a result of AuNCs immobilization on the zeolite surface. The immune response studies showed that the hybrid nanocomposites are effective in reducing inflammation, which combined with a greater attachment of vitronectin, may promote wound healing. The hemostatic potential of the nanocomposite could be directly correlated with their immunomodulatory and anti-haemorrhagic properties. Together, the hybrid nanoengineered material developed in this work could provide a new avenue to tackle life-threatening injuries in civilian and other emergencies.

Original languageEnglish
Pages (from-to)19936-19945
Number of pages10
JournalNanoscale
Volume13
Issue number47
DOIs
Publication statusPublished - 21 Dec 2021
Externally publishedYes

Keywords

  • Polymers
  • Nanocomposites
  • Zeolites
  • anti-haemorrhagic properties
  • anti-inflammatory properties

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