Ultrasound characterization of acute myocardial ischemia by quantitative texture analysis

David D. McPherson, Philip E. Aylward, Boyd M. Knosp, Judy A. Bean, Richard E. Kerber, Steve M. Collins, David J. Skorton

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

In this study we tested the efficacy of quantitative texture analysis in the identification of acute myocardial ischemia using an ultrasound data acquisition system that digitizes and stores echocardiographic data in polar format. In nine closed-chest dogs, data were acquired before and after coronary occlusion using a 2.4 MHz echocardiographic system. Regions of interest were analyzed at end-diastole and end-systole from the ischemic area and normal area at the same depth of field. Ultrasound data were evaluated using previously reported quantitative gray level texture measures. After occlusion, texture changes indicative of ischemia were found in systolic images. The directional component of the data analysis was important; analysis in the azimuthal direction was more accurate than in the axial direction. Six texture measures exhibited significant changes in the ischemic region from control to occlusion when analyzing data in the azimuthal direction. One false positive result occurred (significant texture change in the normal region from control to occlusion) in the azimuthal direction. Several false positive alterations in the normal regions from control to occlusion were found when the texture was evaluated in the axial direction. For accurate assessment of ischemic changes, preocclusion image data were required. We conclude that quantitative echocardiographic texture analysis using polar format data can identify subtle changes in myocardial texture such as that due to acute ischemia, using data acquired through the chest wall.

Original languageEnglish
Pages (from-to)227-240
Number of pages14
JournalUltrasonic Imaging
Volume8
Issue number4
DOIs
Publication statusPublished - Oct 1986
Externally publishedYes

Bibliographical note

Funding Information:
study was supported Center of Research

Funding Information:
in part by Program Project Grant HL14388, and in Ischemic Heart Disease HL32295, from the

Funding Information:
Heart, Lung and Blood Institute, National MD. and by a grant from the U.S. Veterans

Funding Information:
Dr. McPherson was an Alberta Heritage Foundation and a Canadian Heart Foundation Fellow. Dr. Aylward Foundation of Australia Overseas Research Fellow. recipient Research Career Development Award K04HL01290 Heart, and Blood Institute, National Institutes of MD.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

  • Echocardiography
  • myocardial ischemia
  • texture analysis
  • ultrasound tissue characterization

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