Ultrastructural evidence for gamma aminobutyric acid-immunoreactive synapses on somatostatin-immunoreactive perikarya in the periventricular anterior hypothalamus

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    Abstract

    Somatostatin-immunoreactive perikarya in the periventricular anterior hypothalamus were demonstrated to be surrounded by gamma aminobutyric acid GABA-immunoreactive nerve terminals, by combining pre-embedding im-munocytochemistry for somatostatin and gold labelling post-embedding immunocytochemistry for GAB A. Ultrastructural studies revealed that in each 100-nm section, cells immunoreactive for somatostatin (n = 62) were contacted by a mean of 7.6 ±0.4 terminal profiles of which 3.0 ±0.3 (40%) were GABA-immunoreactive. Most GABA-immunoreactive terminals contained clear rounded vesicles and, where synaptic specializations were well demonstrated, appeared to be symmetric. The finding provides evidence that there is a significant GABA input to somatostatin neurons, an observation strengthening the hypothesis that GABA may inhibit somatostatin neurons, thereby causing increased secretion of growth hormone.

    Original languageEnglish
    Pages (from-to)268-872
    Number of pages605
    JournalNeuroendocrinology
    Volume46
    Issue number3
    DOIs
    Publication statusPublished - 1987

    Keywords

    • Anterior hypothalamus
    • Gamma aminobutyric acid
    • Growth hormone
    • Immunocytochemistry
    • Somatostatin

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